Placental passage of protopine in an ex vivo human perfusion system.
Sign Up to like & getrecommendations! Published in 2022 at "Planta medica"
DOI: 10.1055/a-1829-9546
Abstract: The placental passage of protopine was investigated with a human ex vivo placental perfusion model. The model was first validated with diazepam and citalopram, two compounds known to cross the placental barrier, and antipyrine as… read more here.
Keywords: perfusion; protopine; passage protopine; vivo ... See more keywords
Protopine triggers apoptosis via the intrinsic pathway and regulation of ROS/PI3K/Akt signalling pathway in liver carcinoma
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DOI: 10.1186/s12935-021-02105-5
Abstract: Background Protopine is an isoquinoline alkaloid that possesses various biological activities including the anti-tumour activity. However, the effects of protopine on liver carcinoma cells are still elusive. The aim of this study is to examine… read more here.
Keywords: protopine; pi3k akt; liver carcinoma; via intrinsic ... See more keywords
Protopine alleviates lipopolysaccharide-triggered intestinal epithelial cell injury through retarding the NLRP3 and NF-κB signaling pathways to reduce inflammation and oxidative stress.
Sign Up to like & getrecommendations! Published in 2022 at "Allergologia et immunopathologia"
DOI: 10.15586/aei.v50i6.669
Abstract: BACKGROUND Inflammatory bowel disease (IBD) is a common chronic intestinal disease. Protopine isolated from different plants has been investigated to understand its special functions on varied diseases. However, the regulatory effects of protopine on the… read more here.
Keywords: cell; protopine; oxidative stress; inflammation oxidative ... See more keywords