Integration of virtual screening and computational simulation identifies photodynamic therapeutics against human Protoporphyrinogen Oxidase IX (hPPO)
Sign Up to like & getrecommendations! Published in 2020 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2018.04.009
Abstract: Abstract Photodynamic therapy (PDT) is a rapidly evolving area of cancer management against solid tumors. PDT is either administrated by injecting photosensitizer (porphyrins) or by accumulation of intracellular protoporphyrin IX via the inhibition of human… read more here.
Keywords: human protoporphyrinogen; hppo; protoporphyrinogen oxidase; oxidase hppo ... See more keywords
The hydrogen bonding network involved Arg59 in human protoporphyrinogen IX oxidase is essential for enzyme activity.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.03.124
Abstract: Protoporphyrinogen IX oxidase (PPO) is the last common enzyme in chlorophyll and heme biosynthesis pathways. In human, point mutations on PPO are responsible for the dominantly inherited disorder disease, Variegate Porphyria (VP). Of the VP-causing… read more here.
Keywords: network; protoporphyrinogen oxidase; enzyme; hydrogen bonding ... See more keywords
Compositional differences in hybrids between protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide-resistant transgenic rice and weedy rice accessions.
Sign Up to like & getrecommendations! Published in 2020 at "Food chemistry"
DOI: 10.1016/j.foodchem.2020.128584
Abstract: We characterized the metabolites in grains of transgenic protoporphyrinogen IX oxidase-inhibiting herbicide-resistant rice and weedy accessions using GC-MS and examined whether the chemical composition of their hybrids differed from that of the parents. We found… read more here.
Keywords: rice; protoporphyrinogen oxidase; rice weedy; herbicide resistant ... See more keywords
Novel phenoxy-(trifluoromethyl)pyridine-2-pyrrolidinone-based inhibitors of protoporphyrinogen oxidase: Design, synthesis, and herbicidal activity.
Sign Up to like & getrecommendations! Published in 2020 at "Pesticide biochemistry and physiology"
DOI: 10.1016/j.pestbp.2020.104684
Abstract: As important chemical pesticides, protoporphyrinogen oxidase (PPO, EC 1.3.3.4) herbicides play a vital role in weed management. Herein, in a search for novel PPO herbicides, a series of phenoxypyridine-2-pyrrolidinone derivatives were synthesized and their herbicidal… read more here.
Keywords: protoporphyrinogen oxidase; pyrrolidinone; phenoxy trifluoromethyl; compound ... See more keywords
Acute hepatic porphyrias: Identification of 46 hydroxymethylbilane synthase, 11 coproporphyrinogen oxidase, and 20 protoporphyrinogen oxidase novel mutations.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular genetics and metabolism"
DOI: 10.1016/j.ymgme.2018.10.008
Abstract: The acute hepatic porphyrias (AHPs) are inborn errors of heme biosynthesis, which include three autosomal dominant porphyrias, Acute Intermittent Porphyria (AIP), Hereditary Coproporphyria (HCP), and Variegate Porphyria (VP), and the ultra-rare autosomal recessive porphyria, δ-Aminolevulinic… read more here.
Keywords: hydroxymethylbilane synthase; oxidase; acute hepatic; hepatic porphyrias ... See more keywords
Discovery of N-Phenylaminomethylthioacetylpyrimidine-2,4-diones as Protoporphyrinogen IX Oxidase Inhibitors through a Reaction Intermediate Derivation Approach.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c00796
Abstract: Protoporphyrinogen oxidase (PPO, EC 1.3.3.4) is an effective target for green herbicide discovery. In this work, we reported the unexpected discovery of a novel series of N-phenylaminomethylthioacetylpyrimidine-2,4-diones (2-6) as promising PPO inhibitors based on investigating… read more here.
Keywords: protoporphyrinogen oxidase; discovery; phenylaminomethylthioacetylpyrimidine diones;
Synthesis and Herbicidal Activity of Pyrido[2,3-d]pyrimidine-2,4-dione-Benzoxazinone Hybrids as Protoporphyrinogen Oxidase Inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.7b01990
Abstract: To search for new protoporphyrinogen oxidase (PPO, EC 1.3.3.4) inhibitors with improved bioactivity, a series of novel pyrido[2,3-d]pyrimidine-2,4-dione-benzoxazinone hybrids, 9-13, were designed and synthesized. Several compounds with improved tobacco PPO (mtPPO)-inhibiting and promising herbicidal activities… read more here.
Keywords: dione; protoporphyrinogen oxidase; dione benzoxazinone; pyrimidine dione ... See more keywords
Two isoforms of Arabidopsis protoporphyrinogen oxidase localize in different plastidal membranes
Sign Up to like & getrecommendations! Published in 2023 at "Plant Physiology"
DOI: 10.1093/plphys/kiad107
Abstract: Abstract All land plants encode 2 isoforms of protoporphyrinogen oxidase (PPO). While PPO1 is predominantly expressed in green tissues and its loss is seedling-lethal in Arabidopsis (Arabidopsis thaliana), the effects of PPO2 deficiency have not… read more here.
Keywords: protoporphyrinogen oxidase; two isoforms; isoforms arabidopsis; ppo2 ... See more keywords
How protoporphyrinogen IX oxidase inhibitors and transgenesis contribute to elucidate plant tetrapyrrole pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Porphyrins and Phthalocyanines"
DOI: 10.1142/s1088424619300076
Abstract: Several families of herbicides, especially diphenyl ether (DPE) and pyrimidinedione, target the plant tetrapyrrole biosynthesis pathways and in particular one key enzyme, protoporphyrinogen IX oxidase (PPO). When plants are treated with DPE or pyrimidinedione, an accumulation… read more here.
Keywords: transgenic crops; plant tetrapyrrole; protoporphyrinogen oxidase; tetrapyrrole pathway ... See more keywords