FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs
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DOI: 10.1126/scisignal.aar5536
Abstract: Ligand binding induces conformational changes in FZD5, activation of heterotrimeric G proteins, and Gq-dependent signaling. FZD5 as a prototypical GPCR Despite exhibiting sequence and structural similarity to other classes of G protein–coupled receptors (GPCRs), class… read more here.
Keywords: fzd5; class; gpcr; activation ... See more keywords