Metalloaminopeptidases of the Protozoan Parasite Plasmodium falciparum as Targets for the Discovery of Novel Antimalarial Drugs.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c01721
Abstract: Malaria poses a significant threat to approximately half of the world's population with an annual death toll close to half a million. The emergence of resistance to front-line antimalarials in the most lethal human parasite… read more here.
Keywords: novel antimalarial; plasmodium falciparum; metalloaminopeptidases protozoan; protozoan parasite ... See more keywords
A Microbial Piñata: Bacterial Endosymbionts of Trichomonas vaginalis Come in Different Flavors
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DOI: 10.1128/mbio.01323-22
Abstract: The protozoan parasite Trichomonas vaginalis causes trichomoniasis, a prevalent human urogenital infection with significant morbidity that is commonly associated with vaginal dysbiosis. Exacerbation of T. vaginalis pathogenicity has been related to endosymbionts, including mycoplasma, and… read more here.
Keywords: ata bacterial; protozoan parasite; trichomonas vaginalis; mycoplasma ... See more keywords
Proteomic analysis of Atg8-dependent recruitment of phagosomal proteins in the enteric protozoan parasite Entamoeba histolytica
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.961645
Abstract: Autophagy is one of the bulk degradation systems and is conserved throughout eukaryotes. In the enteric protozoan parasite Entamoeba histolytica, the causative agent of human amebiasis, Atg8 is not exclusively involved in autophagy per se… read more here.
Keywords: atg8 dependent; histolytica; atg8; parasite entamoeba ... See more keywords
The In Silico Identification of Potential Members of the Ded1/DDX3 Subfamily of DEAD-Box RNA Helicases from the Protozoan Parasite Leishmania infantum and Their Analyses in Yeast
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DOI: 10.3390/genes12020212
Abstract: DEAD-box RNA helicases are ubiquitous proteins found in all kingdoms of life and that are associated with all processes involving RNA. Their central roles in biology make these proteins potential targets for therapeutic or prophylactic… read more here.
Keywords: ded1 ddx3; dead box; box; ddx3 subfamily ... See more keywords
The Complexity of Interferon Signaling in Host Defense against Protozoan Parasite Infection
Sign Up to like & getrecommendations! Published in 2023 at "Pathogens"
DOI: 10.3390/pathogens12020319
Abstract: Protozoan parasites, such as Plasmodium, Leishmania, Toxoplasma, Cryptosporidium, and Trypanosoma, are causative agents of health-threatening diseases in both humans and animals, leading to significant health risks and socioeconomic losses globally. The development of effective therapeutic… read more here.
Keywords: parasite infection; defense; protozoan parasite; host ... See more keywords