The emerging paradigm of calcium homeostasis as a new therapeutic target for protozoan parasites.
Sign Up to like & getrecommendations! Published in 2021 at "Medicinal research reviews"
DOI: 10.1002/med.21804
Abstract: Calcium channels (CCs), a group of ubiquitously expressed membrane proteins, are involved in many pathophysiological processes of protozoan parasites. Our understanding of CCs in cell signaling, organelle function, cellular homeostasis, and cell cycle control has… read more here.
Keywords: calcium; calcium homeostasis; protozoan parasites; new therapeutic ... See more keywords
3'nucleotidase/nuclease in protozoan parasites: Molecular and biochemical properties and physiological roles.
Sign Up to like & getrecommendations! Published in 2017 at "Experimental parasitology"
DOI: 10.1016/j.exppara.2017.06.001
Abstract: 3'-nucleotidase/nuclease (3'NT/NU) is a bi-functional enzyme that is able to hydrolyze 3'-monophosphorylated nucleotides and nucleic acids. This review summarizes the major molecular and biochemical properties of this enzyme in different trypanosomatid species. Sequence analysis of… read more here.
Keywords: nuclease protozoan; protozoan parasites; parasites molecular; biochemical properties ... See more keywords
Target acquired: transcriptional regulators as drug targets for protozoan parasites.
Sign Up to like & getrecommendations! Published in 2021 at "International journal for parasitology"
DOI: 10.1016/j.ijpara.2020.12.007
Abstract: Protozoan parasites are single-celled eukaryotic organisms that cause significant human disease and pose a substantial health and socioeconomic burden worldwide. They are responsible for at least 1 million deaths annually. The treatment of such diseases… read more here.
Keywords: drug targets; protozoan parasites; transcriptional regulators; target acquired ... See more keywords
Drug Resistance in Protozoan Parasites: An Incessant Wrestle for Survival.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2019.01.023
Abstract: Nowadays, drug resistance in parasites is considered to be one of the foremost concerns in health and disease management. It is interconnected worldwide and undermines the health of millions of people, threatening to grow worse.… read more here.
Keywords: drug resistance; resistance; protozoan parasites; resistance protozoan ... See more keywords
Protein acetylation in the critical biological processes in protozoan parasites.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in parasitology"
DOI: 10.1016/j.pt.2021.04.008
Abstract: Protein lysine acetylation has emerged as a major regulatory post-translational modification in different organisms, present not only on histone proteins affecting chromatin structure and gene expression but also on nonhistone proteins involved in several cellular… read more here.
Keywords: protein acetylation; acetylation; protozoan parasites; critical biological ... See more keywords
Prevalence of intestinal protozoan parasites among school children in africa: A systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0009971
Abstract: Introduction Parasitic infections, especially intestinal protozoan parasites (IPPs) remain a significant public health issue in Africa, where many conditions favour the transmission and children are the primary victims. This systematic review and meta-analysis was carried… read more here.
Keywords: prevalence; intestinal protozoan; protozoan parasites; school children ... See more keywords
Viral endosymbiotic infection of protozoan parasites: How it influences the development of cutaneous leishmaniasis
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1010910
Abstract: The pervasiveness of viral infectious agents, capable of parasitizing living organisms all along the evolutionary spectrum, has obligated hosts to evolve defense mechanisms that control viral infection. Elucidation of host–pathogen interactions in model organisms has… read more here.
Keywords: viral endosymbiotic; infection; infection protozoan; protozoan parasites ... See more keywords
Biogenesis of extracellular vesicles in protozoan parasites: The ESCRT complex in the trafficking fast lane?
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1011140
Abstract: Extracellular vesicles (EVs) provide a central mechanism of cell–cell communication. While EVs are found in most organisms, their pathogenesis-promoting roles in parasites are of particular interest given the potential for medical insight and consequential therapeutic… read more here.
Keywords: extracellular vesicles; biogenesis extracellular; biogenesis; protozoan parasites ... See more keywords
Parasite Polyamines as Pharmaceutical Targets.
Sign Up to like & getrecommendations! Published in 2017 at "Current pharmaceutical design"
DOI: 10.2174/1381612823666170601101644
Abstract: There is an urgent need for the identification and validation of new therapeutic targets in protozoan parasites because currently available drugs are limited in number and usefulness, and no vaccines are available. The discovery that… read more here.
Keywords: parasite polyamines; polyamines pharmaceutical; pharmaceutical targets; protozoan parasites ... See more keywords
An Investigation of Parasitic Protozoa in Drinking Water in Samarra, Iraq.
Sign Up to like & getrecommendations! Published in 2022 at "Archives of Razi Institute"
DOI: 10.22092/ari.2022.357106.1977
Abstract: Protozoan parasites are very important in drinking water production systems because their cystic forms are stable in the environment and resistant to conventional disinfection methods. The present study aimed to investigate protozoan parasites in the… read more here.
Keywords: drinking water; water; protozoan parasites; samarra iraq ... See more keywords
Non-coding RNAs in Host–Pathogen Interactions: Subversion of Mammalian Cell Functions by Protozoan Parasites
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2017.00474
Abstract: Pathogens have evolved mechanisms to modulate host cell functions and avoid recognition and destruction by the host damage response. For many years, researchers have focused on proteins as the main effectors used by pathogens to… read more here.
Keywords: protozoan parasites; coding rnas; non coding; host ... See more keywords