Lactic Acidosis Together with GM-CSF and M-CSF Induces Human Macrophages toward an Inflammatory Protumor Phenotype
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DOI: 10.1158/2326-6066.cir-18-0749
Abstract: Tumor-derived lactic acid induces human monocytes to differentiate into macrophages with inflammatory immunoregulatory properties, similar to those of macrophages in established tumors. Drugs targeting the glycolytic metabolism of tumor cells might prevent accumulation of protumor… read more here.
Keywords: acidosis; human macrophages; tumor; induces human ... See more keywords