Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition
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DOI: 10.1073/pnas.1707929115
Abstract: Significance Macrophages can be functionally reprogrammed by the tumor microenvironment to further tumor growth and malignancy. In this study, we have discovered that this pathological process is dependent on the ERK5 MAPK. Accordingly, we demonstrated… read more here.
Keywords: erk5; protumor macrophage; macrophage; tumor growth ... See more keywords