CRISPR based editing of SIV proviral DNA in ART treated non-human primates
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-19821-7
Abstract: Elimination of HIV DNA from infected individuals remains a challenge in medicine. Here, we demonstrate that intravenous inoculation of SIV-infected macaques, a well-accepted non-human primate model of HIV infection, with adeno-associated virus 9 (AAV9)-CRISPR/Cas9 gene… read more here.
Keywords: non human; crispr based; dna; based editing ... See more keywords
Elite suppressors have low frequencies of intact HIV-1 proviral DNA.
Sign Up to like & getrecommendations! Published in 2019 at "AIDS"
DOI: 10.1097/qad.0000000000002474
Abstract: : Elite controllers or suppressors (ES) control viral replication without antiretroviral therapy (ART). We used the intact proviral DNA assay to approximate the size of the inducible latent reservoir in ES and found that while… read more here.
Keywords: low frequencies; dna; frequencies intact; suppressors low ... See more keywords
X-Linked RNA-Binding Motif Protein Modulates HIV-1 Infection of CD4+ T Cells by Maintaining the Trimethylation of Histone H3 Lysine 9 at the Downstream Region of the 5′ Long Terminal Repeat of HIV Proviral DNA
Sign Up to like & getrecommendations! Published in 2020 at "mBio"
DOI: 10.1128/mbio.03424-19
Abstract: HIV-1 latency featuring silence of transcription from HIV-1 proviral DNA represents a major obstacle for HIV-1 eradication. Reversible repression of HIV-1 5′-LTR-mediated transcription represents the main mechanism for HIV-1 to maintain latency. The 5′-LTR-driven HIV… read more here.
Keywords: ltr; hiv; transcription; proviral dna ... See more keywords
Intact Proviral DNA Analysis of the Brain Viral Reservoir and Relationship to Neuroinflammation in People with HIV on Suppressive Antiretroviral Therapy
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15041009
Abstract: HIV establishes a persistent viral reservoir in the brain despite viral suppression in blood to undetectable levels on antiretroviral therapy (ART). The brain viral reservoir in virally suppressed HIV+ individuals is not well-characterized. In this… read more here.
Keywords: intact proviral; proviral dna; brain; viral reservoir ... See more keywords