Curcumin‐mediated demethylation of the proximal promoter CpG island enhances the KLF4 recruitment that leads to increased expression of p21Cip1 in vitro
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27442
Abstract: Curcumin, the active component of the spice turmeric, induce global DNA hypomethylation as it has been shown to inhibit DNA methyltransferases. It promotes cell death in cancer cells by arresting in the G1 phase. It… read more here.
Keywords: proximal promoter; promoter; expression; p21 ... See more keywords
Transcription from the proximal promoter of ELAC1, a gene for tRNA repair, is upregulated by interferons.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.11.037
Abstract: tRNase ZS (ELAC1) and TRNT1 function in tRNA recycling. Recently, we have shown that these genes are upregulated in the cells infected with Theiler's mouse encephalitis virus (TMEV), implying that tRNA recycling functions in response… read more here.
Keywords: proximal promoter; ifn; promoter; elac1 gene ... See more keywords
Genome-wide map of proximity linkage to renin proximal promoter in rat.
Sign Up to like & getrecommendations! Published in 2018 at "Physiological genomics"
DOI: 10.1152/physiolgenomics.00132.2017
Abstract: A challenge to understanding enhancer-gene relationships is that enhancers are not always sequentially close to the gene they regulate. Physical proximity mapping through sequencing can provide an unbiased view of the chromatin close to the… read more here.
Keywords: genome wide; renin proximal; proximal promoter; promoter ... See more keywords
Sp1, Instead of AhR, Regulates the Basal Transcription of Porcine CYP1A1 at the Proximal Promoter
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.00927
Abstract: Pigs are commonly used as an animal model to evaluate the toxic effects of exogenous compounds. Cytochrome P450 1A1 (CYP1A1) metabolizes numerous exogenous compounds and is abundantly expressed in the liver, kidneys, and intestines. The… read more here.
Keywords: proximal promoter; expression; cyp1a1; porcine cyp1a1 ... See more keywords