TGFβ instructs mTORC2 to activate PKCβII for increased TWIST1 expression in proximal tubular epithelial cell injury
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14599
Abstract: The plasticity of proximal tubular epithelial cells in response to TGFβ contributes to the expression of TWIST1 to drive renal fibrosis. The mechanism of TWIST1 expression is not known. We show that both PI3 kinase… read more here.
Keywords: cell; proximal tubular; expression; twist1 expression ... See more keywords
Preconditioning of primary human renal proximal tubular epithelial cells without tryptophan increases survival under hypoxia by inducing autophagy
Sign Up to like & getrecommendations! Published in 2017 at "International Urology and Nephrology"
DOI: 10.1007/s11255-017-1596-9
Abstract: PurposeHypoxia plays a significant role in the pathogenesis of acute kidney injury (AKI). Autophagy protects from AKI. Amino acid deprivation induces autophagy. The effect of l-tryptophan depletion on survival and autophagy in cultures of renal… read more here.
Keywords: renal proximal; without tryptophan; tryptophan; autophagy ... See more keywords
Spermidine rescues proximal tubular cells from oxidative stress and necrosis after ischemic acute kidney injury
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Pharmacal Research"
DOI: 10.1007/s12272-017-0957-3
Abstract: Kidney ischemia and reperfusion injury (IRI) is associated with a high mortality rate, which is attributed to tubular oxidative stress and necrosis; however, an effective approach to limit IRI remains elusive. Spermidine, a naturally occurring… read more here.
Keywords: necrosis; stress necrosis; oxidative stress; proximal tubular ... See more keywords
Proximal Tubular Expression Patterns of Megalin and Cubilin in Proteinuric Nephropathies
Sign Up to like & getrecommendations! Published in 2017 at "Kidney International Reports"
DOI: 10.1016/j.ekir.2017.02.012
Abstract: Introduction Receptor-mediated endocytosis is responsible for protein reabsorption in the proximal tubules. For albumin this process involves at least 2 interacting receptors, megalin and cubilin. Albumin is not usually present in the urine, indicating a… read more here.
Keywords: expression; tubular expression; megalin cubilin; proximal tubular ... See more keywords
mTORC1 activation contributes to autophagy inhibition via its recruitment to lysosomes and consequent lysosomal dysfunction in cadmium-exposed rat proximal tubular cells.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2020.111231
Abstract: Autophagy dysregulation is implicated in cadmium (Cd)-induced nephrotoxicity. The mammalian target of rapamycin complex 1 (mTORC1) is a negative regulator of autophagy, but its role in Cd-induced autophagy inhibition and possible regulatory mechanisms remains poorly… read more here.
Keywords: rat proximal; autophagy inhibition; inhibition; mtorc1 activation ... See more keywords
Salt suppresses IFNγ inducible chemokines through the IFNγ-JAK1-STAT1 signaling pathway in proximal tubular cells
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep46580
Abstract: The mechanisms of immunoactivation by salt are now becoming clearer. However, those of immunosuppression remain unknown. Since clinical evidence indicates that salt protects proximal tubules from injury, we investigated mechanisms responsible for salt causing immunosuppression… read more here.
Keywords: jak1 stat1; salt; ifn inducible; stat1 ... See more keywords
The influence of fasudil on renal proximal tubular cell epithelial–mesenchymal transition induced by parathormone
Sign Up to like & getrecommendations! Published in 2017 at "Renal Failure"
DOI: 10.1080/0886022x.2017.1349677
Abstract: Abstract Background: Renal fibrosis is a common pathway through which a variety of chronic kidney diseases progress to end-stage renal disease. Epithelial–mesenchymal transition (EMT) of renal proximal tubular cells is one of the most important… read more here.
Keywords: mesenchymal transition; epithelial mesenchymal; renal proximal; proximal tubular ... See more keywords
Anti-EMT and anti-fibrosis effects of protocatechuic aldehyde in renal proximal tubular cells and the unilateral ureteral obstruction animal model
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2088809
Abstract: Abstract Context Protocatechuic aldehyde (PCA) is a natural product that has various benefits for fibrosis. Objective This study evaluated the effects of PCA on renal fibrosis. Materials and methods Epithelial–mesenchymal transition (EMT) was induced by… read more here.
Keywords: renal proximal; proximal tubular; pca; unilateral ureteral ... See more keywords
Calcium Dobesilate Prevents Diabetic Kidney Disease by Decreasing Bim and Inhibiting Apoptosis of Renal Proximal Tubular Epithelial Cells.
Sign Up to like & getrecommendations! Published in 2017 at "DNA and cell biology"
DOI: 10.1089/dna.2016.3276
Abstract: Apoptosis of renal proximal tubular epithelial cells (PTECs) plays a vital role in the pathogenesis and progression of diabetic kidney disease (DKD). Calcium dobesilate is a vascular protective compound used for treatment of diabetic retinopathy… read more here.
Keywords: calcium dobesilate; renal proximal; apoptosis renal; calcium ... See more keywords
Ablation of TRPC3 compromises bicarbonate and phosphate transporter activity in mice proximal tubular cells
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DOI: 10.1111/1440-1681.13741
Abstract: Proximal tubular (PT) cells reabsorb most calcium (Ca2+), phosphate (PO43−), bicarbonate (HCO3−), and oxalate (C2O42−) ions. We have shown that mice lacking Transient Receptor Potential Canonical 3 (TRPC3−/−) channel are moderately hypercalciuric with presentation of… read more here.
Keywords: tubular cells; proximal tubular; cap; mice ... See more keywords
Functional differentiation and scalable production of renal proximal tubular epithelial cells from human pluripotent stem cells in a dynamic culture system
Sign Up to like & getrecommendations! Published in 2022 at "Cell Proliferation"
DOI: 10.1111/cpr.13190
Abstract: To provide a standardized protocol for large‐scale production of proximal tubular epithelial cells (PTEC) generated from human pluripotent stem cells (hPSC). read more here.
Keywords: pluripotent stem; human pluripotent; proximal tubular; epithelial cells ... See more keywords