TGFβ instructs mTORC2 to activate PKCβII for increased TWIST1 expression in proximal tubular epithelial cell injury
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14599
Abstract: The plasticity of proximal tubular epithelial cells in response to TGFβ contributes to the expression of TWIST1 to drive renal fibrosis. The mechanism of TWIST1 expression is not known. We show that both PI3 kinase… read more here.
Keywords: cell; proximal tubular; expression; twist1 expression ... See more keywords
CCDC158: A novel regulator in renal proximal tubular endocytosis unveiled through exome sequencing and interactome analysis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.31447
Abstract: Renal proximal tubular reabsorption of proteins and polypeptides is tightly regulated by a concerted action of the multi‐ligand receptors with subsequent processing from the clathrin‐coated pits to early/recycling and late endosomes and towards lysosomes. We… read more here.
Keywords: endocytosis; ccdc158; proximal tubular; tubular endocytosis ... See more keywords
Preconditioning of primary human renal proximal tubular epithelial cells without tryptophan increases survival under hypoxia by inducing autophagy
Sign Up to like & getrecommendations! Published in 2017 at "International Urology and Nephrology"
DOI: 10.1007/s11255-017-1596-9
Abstract: PurposeHypoxia plays a significant role in the pathogenesis of acute kidney injury (AKI). Autophagy protects from AKI. Amino acid deprivation induces autophagy. The effect of l-tryptophan depletion on survival and autophagy in cultures of renal… read more here.
Keywords: renal proximal; without tryptophan; tryptophan; autophagy ... See more keywords
Spermidine rescues proximal tubular cells from oxidative stress and necrosis after ischemic acute kidney injury
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Pharmacal Research"
DOI: 10.1007/s12272-017-0957-3
Abstract: Kidney ischemia and reperfusion injury (IRI) is associated with a high mortality rate, which is attributed to tubular oxidative stress and necrosis; however, an effective approach to limit IRI remains elusive. Spermidine, a naturally occurring… read more here.
Keywords: necrosis; stress necrosis; oxidative stress; proximal tubular ... See more keywords
Proximal Tubular Expression Patterns of Megalin and Cubilin in Proteinuric Nephropathies
Sign Up to like & getrecommendations! Published in 2017 at "Kidney International Reports"
DOI: 10.1016/j.ekir.2017.02.012
Abstract: Introduction Receptor-mediated endocytosis is responsible for protein reabsorption in the proximal tubules. For albumin this process involves at least 2 interacting receptors, megalin and cubilin. Albumin is not usually present in the urine, indicating a… read more here.
Keywords: expression; tubular expression; megalin cubilin; proximal tubular ... See more keywords
mTORC1 activation contributes to autophagy inhibition via its recruitment to lysosomes and consequent lysosomal dysfunction in cadmium-exposed rat proximal tubular cells.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2020.111231
Abstract: Autophagy dysregulation is implicated in cadmium (Cd)-induced nephrotoxicity. The mammalian target of rapamycin complex 1 (mTORC1) is a negative regulator of autophagy, but its role in Cd-induced autophagy inhibition and possible regulatory mechanisms remains poorly… read more here.
Keywords: rat proximal; autophagy inhibition; inhibition; mtorc1 activation ... See more keywords
Vitamin K2 Attenuates Mitochondrial Damage in Renal Proximal Tubular Cells.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.5c01320
Abstract: Excessive reactive oxygen species (ROS) levels cause oxidative stress, which can lead to various diseases. Renal failure is associated with oxidative stress and mitochondrial dysfunction. Vitamin K1 (phylloquinone) and K2 (menaquinone) are essential for blood… read more here.
Keywords: renal proximal; damage; tubular cells; oxidative stress ... See more keywords
Reno-protective CT contrast nanoagent targets proximal tubular epithelium for kidney disease imaging and repair in a mouse model
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-64432-9
Abstract: | CT imaging is widely used in clinics for disease diagnosis, but its application in renal function evaluation is limited due to nonspecific distribution and nephrotoxicity of clinical iodinated contrast agents. Herein, we developed an… read more here.
Keywords: tubular epithelium; contrast nanoagent; contrast; proximal tubular ... See more keywords
Salt suppresses IFNγ inducible chemokines through the IFNγ-JAK1-STAT1 signaling pathway in proximal tubular cells
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep46580
Abstract: The mechanisms of immunoactivation by salt are now becoming clearer. However, those of immunosuppression remain unknown. Since clinical evidence indicates that salt protects proximal tubules from injury, we investigated mechanisms responsible for salt causing immunosuppression… read more here.
Keywords: jak1 stat1; salt; ifn inducible; stat1 ... See more keywords
The influence of fasudil on renal proximal tubular cell epithelial–mesenchymal transition induced by parathormone
Sign Up to like & getrecommendations! Published in 2017 at "Renal Failure"
DOI: 10.1080/0886022x.2017.1349677
Abstract: Abstract Background: Renal fibrosis is a common pathway through which a variety of chronic kidney diseases progress to end-stage renal disease. Epithelial–mesenchymal transition (EMT) of renal proximal tubular cells is one of the most important… read more here.
Keywords: mesenchymal transition; epithelial mesenchymal; renal proximal; proximal tubular ... See more keywords
Anti-EMT and anti-fibrosis effects of protocatechuic aldehyde in renal proximal tubular cells and the unilateral ureteral obstruction animal model
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2088809
Abstract: Abstract Context Protocatechuic aldehyde (PCA) is a natural product that has various benefits for fibrosis. Objective This study evaluated the effects of PCA on renal fibrosis. Materials and methods Epithelial–mesenchymal transition (EMT) was induced by… read more here.
Keywords: renal proximal; proximal tubular; pca; unilateral ureteral ... See more keywords