Role of Nampt-Sirt6 Axis in Renal Proximal Tubules in Extracellular Matrix Deposition in Diabetic Nephropathy.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.03.024
Abstract: Nicotinamide adenine dinucleotide (NAD+) metabolism plays a critical role in kidneys. We previously reported that decreased secretion of a NAD+ precursor, nicotinamide mononucleotide (NMN), from proximal tubules (PTs) can trigger diabetic albuminuria. In the present… read more here.
Keywords: diabetic nephropathy; nampt sirt6; role; mice ... See more keywords
micro-RNA-486-5p protects against kidney ischemic injury and modifies the apoptotic transcriptome in proximal tubules.
Sign Up to like & getrecommendations! Published in 2021 at "Kidney international"
DOI: 10.1016/j.kint.2021.05.034
Abstract: Acute kidney injury (AKI) carries high morbidity and mortality, and effective treatments are lacking. Preclinical models support involvement of micro-RNAs (miRs) in AKI pathogenesis, although effects on the kidney transcriptome are unclear. We previously showed… read more here.
Keywords: aki; ischemic injury; injury; proximal tubules ... See more keywords
Determination of a microRNA signature of protective kidney ischemic preconditioning originating from proximal tubules
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-89195-3
Abstract: Ischemic preconditioning (IPC) is effective in limiting subsequent ischemic acute kidney injury in experimental models. MicroRNAs are an important class of post-transcriptional regulator and show promise as biomarkers of kidney injury. We evaluated the time-… read more here.
Keywords: microrna signature; ischemic preconditioning; proximal tubules; injury ... See more keywords
Abstract 077: Proximal Tubule-Specific Deletion of the NHE3 (na + /h + Exchanger 3) in the Kidney Attenuates Angiotensin II-Induced Hypertension in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Hypertension"
DOI: 10.1161/hyp.74.suppl_1.077
Abstract: The Na + /H + exchanger 3 (NHE3), a ~85 kDa protein encoded by the SLC9A3 gene, is the most important Na + transporter in the proximal tubules of the kidney. Angiotensin II (ANG II)… read more here.
Keywords: induced hypertension; nhe3; ang; mice ... See more keywords
Regeneration after acute kidney injury requires PTIP mediated epigenetic modifications.
Sign Up to like & getrecommendations! Published in 2020 at "JCI insight"
DOI: 10.1172/jci.insight.130204
Abstract: Adult renal proximal tubules are composed of terminally differentiated epithelial cells that exhibit few signs of proliferation over time. However, upon acute kidney injury (AKI), surviving epithelial cells can re-enter the mitotic cycle and express… read more here.
Keywords: kidney injury; acute kidney; proximal tubules; histone ... See more keywords
TNF-α induces Claudin-1 expression in renal tubules in Alport mice
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0265081
Abstract: Claudin-1 (CL-1) is responsible for the paracellular barrier function of glomerular parietal epithelial cells (PEC) in kidneys, but the role of CL-1 in proximal tubules remains to be elucidated. In this study, to evaluate CL-1… read more here.
Keywords: proximal tubules; kidney; proximal tubular; expression ... See more keywords
Na+/HCO3- Cotransporter NBCn2 Mediates HCO3- Reclamation in the Apical Membrane of Renal Proximal Tubules.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2016080930
Abstract: The kidney maintains systemic acid-base balance by reclaiming from the renal tubule lumen virtually all HCO3- filtered in glomeruli and by secreting additional H+ to titrate luminal buffers. For proximal tubules, which are responsible for… read more here.
Keywords: apical membrane; hco3 reclamation; proximal tubules; nbcn2 ... See more keywords
Light Chain Restriction in Proximal Tubules—Implications for Light Chain Proximal Tubulopathy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.723758
Abstract: Monoclonal gammopathy (MG) causes various nephropathies, which may suffice for cytoreductive therapy even in the absence of diagnostic criteria for multiple myeloma or B-cell non-Hodgkin lymphoma. The aim of this study was to better understand… read more here.
Keywords: light chain; proximal tubules; restriction; restriction proximal ... See more keywords
Phosphorus Localization and Its Involvement in the Formation of Concentrated Uranium in the Renal Proximal Tubules of Rats Exposed to Uranyl Acetate
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20194677
Abstract: Although the kidneys comprise a critical target of uranium exposure, the dynamics of renal uranium distribution have remained obscure. Uranium is considered to function physiologically in the form of uranyl ions that have high affinity… read more here.
Keywords: phosphorus; formation; rats exposed; uranyl acetate ... See more keywords