Developing Covalent Protein Drugs via Proximity-Enabled Reactive Therapeutics
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DOI: 10.1016/j.cell.2020.05.028
Abstract: Small molecule covalent drugs provide desirable therapeutic properties over noncovalent ones for treating challenging diseases. The potential of covalent protein drugs, however, remains unexplored due to protein's inability to bind targets covalently. We report a… read more here.
Keywords: protein; covalent protein; protein drugs; proximity enabled ... See more keywords