Effects of PrPC on DF‐1 cells’ biological processes and RNA‐seq‐based analysis of differential genes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26447
Abstract: To reveal the effects of PrPC on cells’ biological processes and on gene expression. We established stable DF‐1 (PrPC‐knockdown (KD)) cells, and combined with DF‐1 (wt) and DF‐1 (PrPC‐overexpression (OE)) cells that we previously established… read more here.
Keywords: cells biological; effects prpc; prpc; prpc cells ... See more keywords
The function of the cellular prion protein in health and disease
Sign Up to like & getrecommendations! Published in 2017 at "Acta Neuropathologica"
DOI: 10.1007/s00401-017-1790-y
Abstract: The essential role of the cellular prion protein (PrPC) in prion disorders such as Creutzfeldt–Jakob disease is well documented. Moreover, evidence is accumulating that PrPC may act as a receptor for protein aggregates and transduce… read more here.
Keywords: protein; prpc; prion; disease ... See more keywords
Epigenetic Control of the Notch and Eph Signaling Pathways by the Prion Protein: Implications for Prion Diseases
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1193-7
Abstract: Among the ever-growing number of self-replicating proteins involved in neurodegenerative diseases, the prion protein PrP remains the most infamous for its central role in transmissible spongiform encephalopathies (TSEs). In these diseases, pathogenic prions propagate through… read more here.
Keywords: prpc; prion; notch eph; eph signaling ... See more keywords
The Prion Concept and Synthetic Prions.
Sign Up to like & getrecommendations! Published in 2017 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2017.06.002
Abstract: Transmissible spongiform encephalopathies or prion diseases are a group of fatal neurodegenerative diseases caused by unconventional infectious agents, known as prions (PrPSc). Prions derive from a conformational conversion of the normally folded prion protein (PrPC),… read more here.
Keywords: concept synthetic; prion concept; prpc; prion ... See more keywords
Dissecting the copper bioinorganic chemistry of the functional and pathological roles of the prion protein: Relevance in Alzheimer's disease and cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2021.102098
Abstract: The cellular prion protein (PrPC) is a metal-binding biomolecule that can interact with different protein partners involved in pivotal physiological processes, such as neurogenesis and neuronal plasticity. Recent studies profile copper and PrPC as important… read more here.
Keywords: prpc; chemistry; copper; disease ... See more keywords
Aptamer-Induced-Dimerization Strategy Attenuates AβO Toxicity through Modulating the Trophic Activity of PrPC Signaling.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c00287
Abstract: Current therapeutic strategies for Alzheimer's disease (AD) mainly focus on amyloid β oligomer (AβO) formation or clearance. However, most of them have failed to yield good clinical results. There is an urgent need to explore… read more here.
Keywords: trophic activity; aptamer induced; dimerization; strategy ... See more keywords
Rapid ex vivo reverse genetics identifies the essential determinants of prion protein toxicity
Sign Up to like & getrecommendations! Published in 2022 at "Brain Pathology"
DOI: 10.1111/bpa.13130
Abstract: The cellular prion protein PrPC mediates the neurotoxicity of prions and other protein aggregates through poorly understood mechanisms. Antibody-derived ligands against the globular domain of PrPC (GDL) can also initiate neurotoxicity by inducing an intramolecular… read more here.
Keywords: prion; rapid vivo; prion protein; toxicity ... See more keywords
Abstract 325: The cellular prion protein is involved in the modulation of Wnt signaling in glioblastoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-325
Abstract: Glioblastoma (GBM) is an aggressive, invasive and therapy resistant brain tumor. Our research group has been unraveling the role of the cellular prion protein (PrPC) on GBM biology. PrPC is a scaffold protein that interacts… read more here.
Keywords: beta catenin; glioblastoma; prpc; gbm ... See more keywords
Cardiac glycoside-mediated turnover of Na, K-ATPases as a rational approach to reducing cell surface levels of the cellular prion protein
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0270915
Abstract: It is widely anticipated that a reduction of brain levels of the cellular prion protein (PrPC) can prolong survival in a group of neurodegenerative diseases known as prion diseases. To date, efforts to decrease steady-state… read more here.
Keywords: prion; cellular prion; prion protein; levels cellular ... See more keywords
Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010013
Abstract: The cellular prion protein PrPC is necessary for prion replication, and its reduction greatly increases life expectancy in animal models of prion infection. Hence the factors controlling the levels of PrPC may represent therapeutic targets… read more here.
Keywords: prpc; regulators prpc; rna interference; novel regulators ... See more keywords
A New Take on Prion Protein Dynamics in Cellular Trafficking
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21207763
Abstract: The mobility of cellular prion protein (PrPC) in specific cell membrane domains and among distinct cell compartments dictates its molecular interactions and directs its cell function. PrPC works in concert with several partners to organize… read more here.
Keywords: prpc; protein dynamics; new take; prion ... See more keywords