Effects of PrPC on DF‐1 cells’ biological processes and RNA‐seq‐based analysis of differential genes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26447
Abstract: To reveal the effects of PrPC on cells’ biological processes and on gene expression. We established stable DF‐1 (PrPC‐knockdown (KD)) cells, and combined with DF‐1 (wt) and DF‐1 (PrPC‐overexpression (OE)) cells that we previously established… read more here.
Keywords: cells biological; effects prpc; prpc; prpc cells ... See more keywords
The function of the cellular prion protein in health and disease
Sign Up to like & getrecommendations! Published in 2017 at "Acta Neuropathologica"
DOI: 10.1007/s00401-017-1790-y
Abstract: The essential role of the cellular prion protein (PrPC) in prion disorders such as Creutzfeldt–Jakob disease is well documented. Moreover, evidence is accumulating that PrPC may act as a receptor for protein aggregates and transduce… read more here.
Keywords: protein; prpc; prion; disease ... See more keywords
Epigenetic Control of the Notch and Eph Signaling Pathways by the Prion Protein: Implications for Prion Diseases
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1193-7
Abstract: Among the ever-growing number of self-replicating proteins involved in neurodegenerative diseases, the prion protein PrP remains the most infamous for its central role in transmissible spongiform encephalopathies (TSEs). In these diseases, pathogenic prions propagate through… read more here.
Keywords: prpc; prion; notch eph; eph signaling ... See more keywords
The Prion Concept and Synthetic Prions.
Sign Up to like & getrecommendations! Published in 2017 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2017.06.002
Abstract: Transmissible spongiform encephalopathies or prion diseases are a group of fatal neurodegenerative diseases caused by unconventional infectious agents, known as prions (PrPSc). Prions derive from a conformational conversion of the normally folded prion protein (PrPC),… read more here.
Keywords: concept synthetic; prion concept; prpc; prion ... See more keywords
Dissecting the copper bioinorganic chemistry of the functional and pathological roles of the prion protein: Relevance in Alzheimer's disease and cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2021.102098
Abstract: The cellular prion protein (PrPC) is a metal-binding biomolecule that can interact with different protein partners involved in pivotal physiological processes, such as neurogenesis and neuronal plasticity. Recent studies profile copper and PrPC as important… read more here.
Keywords: prpc; chemistry; copper; disease ... See more keywords
Aptamer-Induced-Dimerization Strategy Attenuates AβO Toxicity through Modulating the Trophic Activity of PrPC Signaling.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c00287
Abstract: Current therapeutic strategies for Alzheimer's disease (AD) mainly focus on amyloid β oligomer (AβO) formation or clearance. However, most of them have failed to yield good clinical results. There is an urgent need to explore… read more here.
Keywords: trophic activity; aptamer induced; dimerization; strategy ... See more keywords
PrPC controls epithelial-to-mesenchymal transition in EGFR-mutated NSCLC: implications for TKI resistance and patient follow-up
Sign Up to like & getrecommendations! Published in 2024 at "Oncogene"
DOI: 10.1038/s41388-024-03130-0
Abstract: Patients with EGFR-mutated non-small cell lung cancer (NSCLC) benefit from treatment with tyrosine kinase inhibitors (TKI) targeting EGFR. Despite improvements in patient care, especially with the 3rd generation TKI osimertinib, disease relapse is observed in… read more here.
Keywords: tki resistance; mutated nsclc; egfr mutated; prpc ... See more keywords
Rapid ex vivo reverse genetics identifies the essential determinants of prion protein toxicity
Sign Up to like & getrecommendations! Published in 2022 at "Brain Pathology"
DOI: 10.1111/bpa.13130
Abstract: The cellular prion protein PrPC mediates the neurotoxicity of prions and other protein aggregates through poorly understood mechanisms. Antibody-derived ligands against the globular domain of PrPC (GDL) can also initiate neurotoxicity by inducing an intramolecular… read more here.
Keywords: prion; rapid vivo; prion protein; toxicity ... See more keywords
Abstract 325: The cellular prion protein is involved in the modulation of Wnt signaling in glioblastoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-325
Abstract: Glioblastoma (GBM) is an aggressive, invasive and therapy resistant brain tumor. Our research group has been unraveling the role of the cellular prion protein (PrPC) on GBM biology. PrPC is a scaffold protein that interacts… read more here.
Keywords: beta catenin; glioblastoma; prpc; gbm ... See more keywords
Prion protein regulates invasiveness in glioblastoma stem cells
Sign Up to like & getrecommendations! Published in 2024 at "BMC Cancer"
DOI: 10.1186/s12885-024-13285-4
Abstract: Glioblastoma (GBM) is an aggressive brain tumor driven by glioblastoma stem cells (GSCs), which represent an appealing target for therapeutic interventions. The cellular prion protein (PrPC), a scaffold protein involved in diverse cellular processes, interacts… read more here.
Keywords: glioblastoma stem; glioblastoma; gbm; protein ... See more keywords
miR-193b-3p suppresses lung cancer cell migration and invasion through PRNP targeting
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biomedical Science"
DOI: 10.1186/s12929-025-01121-1
Abstract: Tumor metastasis is responsible for approximately 90% of mortality in lung cancer. Understanding the molecular mechanisms of lung cancer metastasis is crucial for developing new treatment strategies. Cellular prion protein (PrPc), encoded by PRNP gene,… read more here.
Keywords: lung cancer; mir 193b; prpc; prnp ... See more keywords