Proline‐rich 11 (PRR11) promotes the progression of cutaneous squamous cell carcinoma by activating the EGFR signaling pathway
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DOI: 10.1002/mc.23510
Abstract: Cutaneous squamous cell carcinoma (cSCC) is one of the most common skin malignancies, and its incidence rate is increasing worldwide. Proline‐rich 11 (PRR11) has been reported to be involved in the occurrence and development of… read more here.
Keywords: cell; cell carcinoma; cutaneous squamous; cscc ... See more keywords
Proline rich 11 (PRR11) overexpression amplifies PI3K signaling and promotes antiestrogen resistance in breast cancer
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DOI: 10.1038/s41467-020-19291-x
Abstract: The 17q23 amplicon is associated with poor outcome in ER+ breast cancers, but the causal genes to endocrine resistance in this amplicon are unclear. Here, we interrogate transcriptome data from primary breast tumors and find… read more here.
Keywords: pi3k; breast; prr11; resistance breast ... See more keywords
In silico analysis reveals PRR11 as a prognostic and oncogenic marker in lung adenocarcinoma
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DOI: 10.1097/md.0000000000033755
Abstract: Lung adenocarcinoma (LUAD) is a common lung cancer. Although there are various treatments for LUAD, its prognosis remains poor. Therefore, it is imperative to identify new targets and develop novel therapeutic strategies. In this study,… read more here.
Keywords: lung adenocarcinoma; expression; analysis; prr11 ... See more keywords
PRR11 Overexpression Facilitates Ovarian Carcinoma Cell Proliferation, Migration, and Invasion Through Activation of the PI3K/AKT/β-Catenin Pathway
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DOI: 10.1159/000493034
Abstract: Background/Aims: Ovarian cancer (OC) is the most lethal gynecologic malignancy, mainly due to the advanced stage at diagnosis in most patients and high rate of relapse. Thus, it is still essential to elucidate the underlying… read more here.
Keywords: cell proliferation; prr11; prr11 expression;
Identification of Anticancer Lead Molecules against PRR11 Protein Target with Combination of Protein Modelling Through Threading Approach, Structure Based Chemical Screening of ZINC Database and Pharmacokinetic Properties
Sign Up to like & getrecommendations! Published in 2018 at "Indian Journal of Pharmaceutical Education and Research"
DOI: 10.5530/ijper.52.3.44
Abstract: PRR11 is a cell cycle regulator involved in pathogenesis of cancer. Therapeutically it has been identified as target to inhibit cancer growth. In this study, we employed in silico strategies for determining 3D structure of… read more here.
Keywords: pharmacokinetic properties; zinc database; prr11; lead molecules ... See more keywords