PRR14 organizes H3K9me3-modified heterochromatin at the nuclear lamina
Sign Up to like & getrecommendations! Published in 2022 at "Nucleus"
DOI: 10.1080/19491034.2023.2165602
Abstract: The eukaryotic genome is organized in three dimensions within the nucleus. Transcriptionally active chromatin is spatially separated from silent heterochromatin, a large fraction of which is located at the nuclear periphery. However, the mechanisms by… read more here.
Keywords: heterochromatin; h3k9me3 modified; prr14; nuclear lamina ... See more keywords
The PRR14 heterochromatin tether encodes modular domains that mediate and regulate nuclear lamina targeting
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cell Science"
DOI: 10.1242/jcs.240416
Abstract: ABSTRACT A large fraction of epigenetically silent heterochromatin is anchored to the nuclear periphery via ‘tethering proteins’ that function to bridge heterochromatin and the nuclear membrane or nuclear lamina. We previously identified a human tethering… read more here.
Keywords: heterochromatin; nuclear lamina; modular domains; prr14 ... See more keywords