Incremental Value of Polygenic Risk Scores in Primary Prevention of Coronary Heart Disease: A Review.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA internal medicine"
DOI: 10.1001/jamainternmed.2022.3171
Abstract: Importance Risk prediction for coronary heart disease (CHD) is a cornerstone of primary prevention strategies. Polygenic risk scores (PRSs) have emerged as a new approach to predict risk in asymptomatic people. Polygenic risk scores for… read more here.
Keywords: risk scores; polygenic risk; prs; risk ... See more keywords
From Basic Science to Clinical Application of Polygenic Risk Scores: A Primer.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2020.3049
Abstract: Importance Polygenic risk scores (PRS) are predictors of the genetic susceptibilities of individuals to diseases. All individuals have DNA risk variants for all common diseases, but genetic susceptibility differences between people reflect the cumulative burden… read more here.
Keywords: medicine; risk; prs; risk variants ... See more keywords
Sex‐specific association between infant caudate volumes and a polygenic risk score for major depressive disorder
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24722
Abstract: Polygenic risk scores for major depressive disorder (PRS‐MDD) have been identified in large genome‐wide association studies, and recent findings suggest that PRS‐MDD might interact with environmental risk factors to shape human limbic brain development as… read more here.
Keywords: risk; prs mdd; prs; sex ... See more keywords
Factors associated with post-relapse survival in patients with recurrent cervical cancer: the value of the inflammation-based Glasgow Prognostic Score
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Gynecology and Obstetrics"
DOI: 10.1007/s00404-018-4993-0
Abstract: AbstractPurposeThe aim of the present study was to assess the value of the Glasgow Prognostic Score (GPS) as a prognostic tool for predicting post-relapse survival (PRS) in patients with recurrent cervical cancer.MethodsWe retrospectively evaluated the… read more here.
Keywords: prs; recurrent cervical; cervical cancer; relapse ... See more keywords
Effective multiple person recognition in random video sequences using a convolutional neural network
Sign Up to like & getrecommendations! Published in 2019 at "Multimedia Tools and Applications"
DOI: 10.1007/s11042-019-7323-z
Abstract: Effective and efficient face recognition through pervasive networks of surveillance cameras is one of the most challenging objectives of advanced computer vision. This study developed a real-time person recognition system (PRS) for the effective identification… read more here.
Keywords: prs; video sequences; person recognition; convolutional neural ... See more keywords
Novel dental phenotype in non-syndromic Pierre Robin Sequence: A retrospective study.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2018.10.031
Abstract: OBJECTIVE The objective was to investigate dental phenotypes in individuals with non-syndromic Pierre Robin Sequence (ns-PRS) and compare the prevalence of these phenotypes with subjects with non-syndromic cleft palate (ns-CP) and a control group with… read more here.
Keywords: phenotype; control group; prs; group ... See more keywords
Associations between major psychiatric disorder polygenic risk scores and blood-based markers in UK biobank
Sign Up to like & getrecommendations! Published in 2021 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2021.06.002
Abstract: Major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BD) have both shared and discrete genetic risk factors and abnormalities in blood-based measures of inflammation and blood-brain barrier (BBB) permeability. The relationships between such genetic… read more here.
Keywords: risk; prs; scz; disorder ... See more keywords
SA87 POLYGENIC RISK SCORE ANALYSES OF SYMPTOMS AND TREATMENT RESPONSE IN A FIRST EPISODE SCHIZOPHRENIA COHORT
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.159
Abstract: Background Schizophrenia (SCZ) is a severe mental disorder affecting ~1% of the population and is characterized by the presence of psychosis and other features, such as negative (i.e., flattened affect and social withdrawal) and disorganization… read more here.
Keywords: schizophrenia; prs; risk score; treatment ... See more keywords
SU40 DISTINCT GENETIC VULNERABILITIES-BY-STRESSFUL LIFE EVENTS INTERACTIONS PROPOSE ADDITIONAL RISK FOR DEPRESSIVE SYMPTOMS
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.229
Abstract: Background Stressful Life Events (SLEs) and genetic risk factors both contribute to the aetiology of Major Depressive Disorder (MDD). Although SLEs are considered to be an environmental factor, studies suggest that they may act in… read more here.
Keywords: depression; risk; prs; mdd ... See more keywords
SU67 INTERACTIVE EFFECTS OF FAMILY HISTORY, POLYGENIC RISK AND AGE ON CORTICAL THICKNESS IN YOUNG PEOPLE AT HIGH GENETIC RISK OF BIPOLAR DISORDER
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.256
Abstract: Background Bipolar Disorder (BP) is a highly heritable mood disorder as demonstrated by a 5 to 10 fold increased risk amongst first degree relatives of BP probands. Structural imaging differences and clinical symptoms have also… read more here.
Keywords: risk; prs; age; familial risk ... See more keywords
M26 THE IMPACT OF BIPOLAR AND SCHIZOPHRENIA POLYGENIC RISK SCORES ON FAMILIAL FEATURES OF BIPOLAR DISORDER
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.333
Abstract: Background In Bipolar Disorder (BD), some endophenotypes such as the occurrence of psychotic symptoms or suicide attempts, the level of psychosocial functioning, disorder subphenotypes like type I/II disorder and comorbidities like alcohol or drug abuse… read more here.
Keywords: schizophrenia; prs; disorder; association ... See more keywords