Incremental Value of Polygenic Risk Scores in Primary Prevention of Coronary Heart Disease: A Review.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA internal medicine"
DOI: 10.1001/jamainternmed.2022.3171
Abstract: Importance Risk prediction for coronary heart disease (CHD) is a cornerstone of primary prevention strategies. Polygenic risk scores (PRSs) have emerged as a new approach to predict risk in asymptomatic people. Polygenic risk scores for… read more here.
Keywords: risk scores; polygenic risk; prs; risk ... See more keywords
Polygenic Risk Score and Upgrading in Patients With Prostate Cancer Receiving Active Surveillance.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2024.5398
Abstract: Importance Active surveillance is the preferred management strategy for patients with low- or favorable intermediate-risk prostate cancer (PCa); however, frequent health care visits can be costly and burdensome to patients. Identifying patients who may benefit… read more here.
Keywords: cancer; active surveillance; risk; surveillance ... See more keywords
Polygenic Risk Scores for Glaucoma Onset in the Ocular Hypertension Treatment Study.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA ophthalmology"
DOI: 10.1001/jamaophthalmol.2024.0151
Abstract: Importance Primary open-angle glaucoma (POAG) is a highly heritable disease, with 127 identified risk loci to date. Polygenic risk score (PRS) may provide a clinically useful measure of aggregate genetic burden and improve patient risk… read more here.
Keywords: treatment; risk; prs; ocular hypertension ... See more keywords
From Basic Science to Clinical Application of Polygenic Risk Scores: A Primer.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2020.3049
Abstract: Importance Polygenic risk scores (PRS) are predictors of the genetic susceptibilities of individuals to diseases. All individuals have DNA risk variants for all common diseases, but genetic susceptibility differences between people reflect the cumulative burden… read more here.
Keywords: medicine; risk; prs; risk variants ... See more keywords
Polygenic Contributions to Lithium Augmentation Outcomes in Unipolar Depression.
Sign Up to like & getrecommendations! Published in 2025 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2025.2039
Abstract: Importance Lithium augmentation is an effective treatment for patients with major depression after inadequate antidepressant response, but therapeutic outcomes vary considerably between individuals. Molecular studies may provide novel insights into treatment prediction and guide personalized… read more here.
Keywords: treatment; response; augmentation; depression ... See more keywords
Development of Polygenic Risk Score for Persistent Albuminuria in Children and Adults With Sickle Cell Anemia
Sign Up to like & getrecommendations! Published in 2025 at "American Journal of Hematology"
DOI: 10.1002/ajh.27678
Abstract: Albuminuria is associated with high‐risk apolipoprotein‐L1 variants (APOL1 G1/G2) in patients with sickle cell anemia (SCA). However, this gene variant does not account for all chronic kidney disease (CKD) risk. We hypothesized that we could… read more here.
Keywords: persistent albuminuria; risk; high risk; prs ... See more keywords
Mitigating type 1 error inflation and power loss in GxE PRS: Genotype–environment interaction in polygenic risk score models
Sign Up to like & getrecommendations! Published in 2024 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22546
Abstract: The use of polygenic risk score (PRS) models has transformed the field of genetics by enabling the prediction of complex traits and diseases based on an individual's genetic profile. However, the impact of genotype–environment interaction… read more here.
Keywords: risk; gxe; prs; type error ... See more keywords
Sex‐specific association between infant caudate volumes and a polygenic risk score for major depressive disorder
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24722
Abstract: Polygenic risk scores for major depressive disorder (PRS‐MDD) have been identified in large genome‐wide association studies, and recent findings suggest that PRS‐MDD might interact with environmental risk factors to shape human limbic brain development as… read more here.
Keywords: risk; prs mdd; prs; sex ... See more keywords
Factors associated with post-relapse survival in patients with recurrent cervical cancer: the value of the inflammation-based Glasgow Prognostic Score
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Gynecology and Obstetrics"
DOI: 10.1007/s00404-018-4993-0
Abstract: AbstractPurposeThe aim of the present study was to assess the value of the Glasgow Prognostic Score (GPS) as a prognostic tool for predicting post-relapse survival (PRS) in patients with recurrent cervical cancer.MethodsWe retrospectively evaluated the… read more here.
Keywords: prs; recurrent cervical; cervical cancer; relapse ... See more keywords
Effective multiple person recognition in random video sequences using a convolutional neural network
Sign Up to like & getrecommendations! Published in 2019 at "Multimedia Tools and Applications"
DOI: 10.1007/s11042-019-7323-z
Abstract: Effective and efficient face recognition through pervasive networks of surveillance cameras is one of the most challenging objectives of advanced computer vision. This study developed a real-time person recognition system (PRS) for the effective identification… read more here.
Keywords: prs; video sequences; person recognition; convolutional neural ... See more keywords
Novel dental phenotype in non-syndromic Pierre Robin Sequence: A retrospective study.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2018.10.031
Abstract: OBJECTIVE The objective was to investigate dental phenotypes in individuals with non-syndromic Pierre Robin Sequence (ns-PRS) and compare the prevalence of these phenotypes with subjects with non-syndromic cleft palate (ns-CP) and a control group with… read more here.
Keywords: phenotype; control group; prs; group ... See more keywords