Therapeutic targeting of PRSS3 to alleviate kidney damage in DKD
Sign Up to like & getrecommendations! Published in 2025 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-025-10060-4
Abstract: As a primary contributor to end-stage renal disease, diabetic kidney disease (DKD) is characterized by metabolic and inflammatory disturbances. Emerging evidence highlights the gut microbiota's contribution to DKD through metabolite interactions. This study investigates the… read more here.
Keywords: prss3; kidney; gut microbiota; damage ... See more keywords
CpG Methylation-Driven Pleiotropic Spliced Isoforms of PRSS3 Facilitate Gastric Intratumor Heterogeneity and Metastasis.
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DOI: 10.1111/cas.70227
Abstract: Investigating the phenotypic contribution of gene‐spliced isoforms to tumor cellular heterogeneity can facilitate the development of innovative strategies for precision medicine. Serine protease 3 (PRSS3), a trypsin‐like protease with four spliced variants (PRSS3‐SVs: PRSS3‐V1 to… read more here.
Keywords: spliced isoforms; prss3; methylation; prss3 svs ... See more keywords
CpG Site-Specific Methylation-Modulated Divergent Expression of PRSS3 Transcript Variants Facilitates Nongenetic Intratumor Heterogeneity in Human Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.831268
Abstract: Background Hepatocellular carcinoma (HCC) is one of the most lethal human tumors with extensive intratumor heterogeneity (ITH). Serine protease 3 (PRSS3) is an indispensable member of the trypsin family and has been implicated in the… read more here.
Keywords: methylation; expression prss3; hcc; expression ... See more keywords