PRT3789 is a First-in-Human SMARCA2-Selective Degrader that Induces Synthetic Lethality in SMARCA4-Mutated Cancers.
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DOI: 10.1158/0008-5472.can-25-1141
Abstract: SMARCA2 and SMARCA4 are the core catalytic subunits of the SWI/SNF chromatin remodeling complex. Approximately 10% of non-small cell lung cancer (NSCLC) patients harbor SMARCA4 mutations, resulting in protein loss or loss-of-function (LOF) alterations. These… read more here.
Keywords: smarca2; mutated cancers; smarca4; prt3789 ... See more keywords
Abstract 1646: Elucidating the molecular mechanism of action of the first in human SMARCA2 selective degrader PRT3789
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DOI: 10.1158/1538-7445.am2025-1646
Abstract: Mammalian SWI/SNF (BAF) complexes play an important role in controlling gene expression by remodeling chromatin. SMARCA2 (BRM) and SMARCA4 (BRG1) are the core catalytic subunits of the SWI/SNF complexes and regulate the composition of nucleosomes… read more here.
Keywords: smarca2; cancer; prt3789; molecular mechanism ... See more keywords