Abstract 2919: Discovery of PRT811, a potent, selective, and orally bioavailable brain penetrant PRMT5 Inhibitor for the treatment of brain tumors
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DOI: 10.1158/1538-7445.am2020-2919
Abstract: Protein arginine methyltransferase 5 (PRMT5) is the major type II PRMT that catalyzes the formation of symmetrical dimethyl arginine (SDMA) on protein substrates and plays important roles in regulating RNA splicing as well as transcription… read more here.
Keywords: brain penetrant; potent selective; prt811 potent; prmt5 ... See more keywords