Characterization of a Dual Function Peptide Cyclase in Graspetide Biosynthesis.
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DOI: 10.1021/acschembio.4c00626
Abstract: Graspetides are a diverse family of ribosomally synthesized and post-translationally modified peptides with unique macrocyclic structures formed by ATP-grasp enzymes. Group 11 graspetides, including prunipeptin, feature both macrolactone and macrolactam cross-links. Despite the known involvement… read more here.
Keywords: atp grasp; graspetide biosynthesis; prub; characterization dual ... See more keywords