Time spent with impaired autoregulation is linked with outcome in severe infant/paediatric traumatic brain injury
Sign Up to like & getrecommendations! Published in 2017 at "Acta Neurochirurgica"
DOI: 10.1007/s00701-017-3308-8
Abstract: BackgroundIt could be shown in traumatic brain injury (TBI) in adults that the functional status of cerebrovascular autoregulation (AR), determined by the pressure reactivity index (PRx), correlates to and even predicts outcome. We investigated PRx,… read more here.
Keywords: autoregulation; outcome; prx; time ... See more keywords
Peroxiredoxin I deficiency increases keratinocyte apoptosis in a skin tumor model via the ROS-p38 MAPK pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.06.047
Abstract: Keratinocyte hyperproliferation is an essential link in skin cancer pathogenesis. Peroxiredoxin I (Prx I) is known to regulate cancer cell proliferation, differentiation, and apoptosis, but its role in skin cancer remains unclear. This study aimed… read more here.
Keywords: apoptosis; prx; skin; skin tumor ... See more keywords
Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-α-Induced Apoptosis via Different Routes.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.01.081
Abstract: There are abundant peroxiredoxin (Prx) enzymes, but an increase of cellular H2O2 level always happens in apoptotic cells. Here, we show that cellular H2O2 switches different apoptosis pathways depending on which type of Prx enzyme is… read more here.
Keywords: absence; apoptosis; tnf induced; prx ... See more keywords
Development of piroxicam mini-tablets enabled by spherical cocrystallization.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119953
Abstract: We examined the potential of the spherical cocrystallization (SCC) technology in simultaneously enhancing tablet manufacturability and dissolution of poorly soluble drugs by developing a mini-tablet formulation of piroxicam. The manufacturing of mini-tablets using a direct… read more here.
Keywords: mini tablets; spherical cocrystallization; prx; development ... See more keywords
Self-association of L-periaxin occurs via its acidic domain and NLS2/NLS3, and affects its trafficking in RSC96 cells
Sign Up to like & getrecommendations! Published in 2017 at "RSC Advances"
DOI: 10.1039/c7ra06853k
Abstract: Periaxin (PRX) protein was first identified in myelinating Schwann cells through the screening of cytoskeleton-associated proteins in peripheral nerve myelination. PRX plays a significant role in myelin sheath formation and myelin stability, and is closely… read more here.
Keywords: rsc96 cells; prx; association; nls2 nls3 ... See more keywords
Galectin-3 down-regulates antioxidant peroxiredoxin-4 in human cardiac fibroblasts: a new pathway to induce cardiac damage.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical science"
DOI: 10.1042/cs20171389
Abstract: Galectin-3 (Gal-3) is increased in heart failure (HF) and promotes cardiac fibrosis and inflammation. We investigated whether Gal-3 modulates oxidative stress in human cardiac fibroblasts, in experimental animal models and in human aortic stenosis (AS).… read more here.
Keywords: gal; prx; cardiac fibroblasts; human cardiac ... See more keywords
Estimating Pressure Reactivity Using Noninvasive Doppler-Based Systolic Flow Index.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of neurotrauma"
DOI: 10.1089/neu.2017.5596
Abstract: The study objective was to derive models that estimate the pressure reactivity index (PRx) using the noninvasive transcranial Doppler (TCD) based systolic flow index (Sx_a) and mean flow index (Mx_a), both based on mean arterial… read more here.
Keywords: index; prx; flow index; pressure reactivity ... See more keywords
Temporal profile of intracranial pressure and cerebrovascular reactivity in severe traumatic brain injury and association with fatal outcome: An observational study
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Medicine"
DOI: 10.1371/journal.pmed.1002353
Abstract: Background Both intracranial pressure (ICP) and the cerebrovascular pressure reactivity represent the dysregulation of pathways directly involved in traumatic brain injury (TBI) pathogenesis and have been used to inform clinical management. However, how these parameters… read more here.
Keywords: outcome; fatal outcome; prx; time ... See more keywords
Protective Role of Peroxiredoxin I in Heat-Killed Staphylococcus Aureus-infected Mice
Sign Up to like & getrecommendations! Published in 2019 at "In Vivo"
DOI: 10.21873/invivo.11535
Abstract: Background/Aim: Staphylococcus aureus (S. aureus) is a major gram-positive pathogen, which can cause toxic and immunogenic injuries both in nosocomial and community-acquired infections. Peroxiredoxin (Prx) I plays crucial roles in cellular apoptosis, proliferation, and signal… read more here.
Keywords: heat killed; prx; staphylococcus aureus; mice ... See more keywords
Ablation of Peroxiredoxin V Exacerbates Ischemia/Reperfusion-Induced Kidney Injury in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Antioxidants"
DOI: 10.3390/antiox9080769
Abstract: Ischemia/reperfusion (I/R) is one of the major causes of acute kidney injury (AKI) and associated with increased mortality and progression to chronic kidney injury (CKI). Molecular mechanisms underlying I/R injury involve the production and excessive… read more here.
Keywords: kidney injury; prx; peroxiredoxin; ischemia reperfusion ... See more keywords
Differences in the Intracellular Localization of Methylated β-Cyclodextrins-Threaded Polyrotaxanes Lead to Different Cellular States
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13060903
Abstract: Activation of autophagy represents a potential therapeutic strategy for the treatment of diseases that are caused by the accumulation of defective proteins and the formation of abnormal organelles. Methylated β-cyclodextrins-threaded polyrotaxane (Me-PRX), a supramolecular structured… read more here.
Keywords: mito porter; cyclodextrins threaded; prx; methylated cyclodextrins ... See more keywords