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   Articles with "prx" as a keyword



Time spent with impaired autoregulation is linked with outcome in severe infant/paediatric traumatic brain injury

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recommendations! Published in 2017 at "Acta Neurochirurgica"

DOI: 10.1007/s00701-017-3308-8

Abstract: BackgroundIt could be shown in traumatic brain injury (TBI) in adults that the functional status of cerebrovascular autoregulation (AR), determined by the pressure reactivity index (PRx), correlates to and even predicts outcome. We investigated PRx,… read more here.

Keywords: autoregulation; outcome; prx; time ... See more keywords

The effects of cerebral pressure autoregulation status and CPP levels on cerebral metabolism in pediatric traumatic brain injury

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recommendations! Published in 2024 at "Acta Neurochirurgica"

DOI: 10.1007/s00701-024-06085-z

Abstract: Cerebral perfusion pressure (CPP) management in the developing child with traumatic brain injury (TBI) is challenging. The pressure reactivity index (PRx) may serve as marker of cerebral pressure autoregulation (CPA) and optimal CPP (CPPopt) may… read more here.

Keywords: pressure; cppopt; cpp; lactate ... See more keywords

Should Patients with Traumatic Brain Injury with Significant Contusions be Treated with Different Neurointensive Care Targets?

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recommendations! Published in 2024 at "Neurocritical Care"

DOI: 10.1007/s12028-024-01954-y

Abstract: Patients with traumatic brain injury (TBI) with large contusions make up a specific TBI subtype. Because of the risk of brain edema worsening, elevated cerebral perfusion pressure (CPP) may be particularly dangerous. The pressure reactivity… read more here.

Keywords: pressure; brain; significant contusions; cppopt ... See more keywords

Does Targeting CPP at CPPopt Actually Improve Cerebrovascular Reactivity? A Secondary Analysis of the COGiTATE Randomized Controlled Trial

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recommendations! Published in 2024 at "Neurocritical Care"

DOI: 10.1007/s12028-024-02168-y

Abstract: The 'CPPopt-Guided Therapy: Assessment of Target Effectiveness' (COGiTATE) randomised controlled trial demonstrated the feasibility and safety of targeting an automated cerebral perfusion pressure (CPP) tailored to optimize cerebrovascular autoregulation (CPPopt) in patients with traumatic brain… read more here.

Keywords: cppopt; cpp; target; prx ... See more keywords
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Peroxiredoxin I deficiency increases keratinocyte apoptosis in a skin tumor model via the ROS-p38 MAPK pathway.

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recommendations! Published in 2020 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2020.06.047

Abstract: Keratinocyte hyperproliferation is an essential link in skin cancer pathogenesis. Peroxiredoxin I (Prx I) is known to regulate cancer cell proliferation, differentiation, and apoptosis, but its role in skin cancer remains unclear. This study aimed… read more here.

Keywords: apoptosis; prx; skin; skin tumor ... See more keywords

Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-Ī±-Induced Apoptosis via Different Routes.

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recommendations! Published in 2019 at "Cell reports"

DOI: 10.1016/j.celrep.2019.01.081

Abstract: There are abundant peroxiredoxin (Prx) enzymes, but an increase of cellular H2O2 level always happens inĀ apoptotic cells. Here, we show that cellular H2O2 switches different apoptosis pathways depending on which type of Prx enzyme is… read more here.

Keywords: absence; apoptosis; tnf induced; prx ... See more keywords

Development of piroxicam mini-tablets enabled by spherical cocrystallization.

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recommendations! Published in 2020 at "International journal of pharmaceutics"

DOI: 10.1016/j.ijpharm.2020.119953

Abstract: We examined the potential of the spherical cocrystallization (SCC) technology in simultaneously enhancing tablet manufacturability and dissolution of poorly soluble drugs by developing a mini-tablet formulation of piroxicam. The manufacturing of mini-tablets using a direct… read more here.

Keywords: mini tablets; spherical cocrystallization; prx; development ... See more keywords

Periaxin gene variants are linked to age-related cataracts in Cx46 deficient lenses

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recommendations! Published in 2025 at "Communications Biology"

DOI: 10.1038/s42003-025-08722-4

Abstract: Genetic predisposition affects cataract severity and progression, but no specific genetic modifier has been identified to date. This study reveals Periaxin (Prx) gene variants that cause four amino acid substitutions in the cytoskeletal scaffold protein… read more here.

Keywords: age related; related cataracts; prx; gene variants ... See more keywords

Self-association of L-periaxin occurs via its acidic domain and NLS2/NLS3, and affects its trafficking in RSC96 cells

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recommendations! Published in 2017 at "RSC Advances"

DOI: 10.1039/c7ra06853k

Abstract: Periaxin (PRX) protein was first identified in myelinating Schwann cells through the screening of cytoskeleton-associated proteins in peripheral nerve myelination. PRX plays a significant role in myelin sheath formation and myelin stability, and is closely… read more here.

Keywords: rsc96 cells; prx; association; nls2 nls3 ... See more keywords

Galectin-3 down-regulates antioxidant peroxiredoxin-4 in human cardiac fibroblasts: a new pathway to induce cardiac damage.

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recommendations! Published in 2018 at "Clinical science"

DOI: 10.1042/cs20171389

Abstract: Galectin-3 (Gal-3) is increased in heart failure (HF) and promotes cardiac fibrosis and inflammation. We investigated whether Gal-3 modulates oxidative stress in human cardiac fibroblasts, in experimental animal models and in human aortic stenosis (AS).… read more here.

Keywords: gal; prx; cardiac fibroblasts; human cardiac ... See more keywords

Estimating Pressure Reactivity Using Noninvasive Doppler-Based Systolic Flow Index.

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recommendations! Published in 2018 at "Journal of neurotrauma"

DOI: 10.1089/neu.2017.5596

Abstract: The study objective was to derive models that estimate the pressure reactivity index (PRx) using the noninvasive transcranial Doppler (TCD) based systolic flow index (Sx_a) and mean flow index (Mx_a), both based on mean arterial… read more here.

Keywords: index; prx; flow index; pressure reactivity ... See more keywords