Dual role of the active-center cysteine in human peroxiredoxin 1: Peroxidase activity and heme binding.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.01.034
Abstract: HBP23, a 23-kDa heme-binding protein identified in rats, is a member of the peroxiredoxin (Prx) family, the primary peroxidases involved in hydrogen peroxide catabolism. Although HBP23 has a characteristic Cys-Pro heme-binding motif, the significance of… read more here.
Keywords: heme; prx1; heme binding; peroxidase activity ... See more keywords
Role of CXCL12-Expressing Mesenchymal Stromal Cell Niches in Maintaining Treatment-Resistant Leukemia Stem Cells
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-117762
Abstract: Chronic myeloid leukemia (CML) results from hematopoietic stem cell (HSC) transformation by the BCR-ABL tyrosine kinase. Tyrosine kinase inhibitors (TKI), although effective in inducing remissions in CML, fail to eradicate leukemia stem cells (LSC) which… read more here.
Keywords: treatment; lsc; cxcl12; mice ... See more keywords
The role of PRX1-expressing cells in periodontal regeneration and wound healing
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2023.978640
Abstract: The ideal outcome of wound healing is the complete restoration of the structure and function of the original tissue. Stem cells are one of the key factors in this process. Currently, the strategy of periodontal… read more here.
Keywords: wound healing; prx1; stem; stem cells ... See more keywords
Prx1 Regulates Thapsigargin-Mediated UPR Activation and Apoptosis
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13112033
Abstract: Endoplasmic reticulum (ER) stress activates the unfolded protein response (UPR) signaling via the accumulation of unfolded and misfolded proteins. ER stress leads to the production of reactive oxygen species (ROS), which are necessary to maintain… read more here.
Keywords: regulates thapsigargin; stress; apoptosis; prx1 ... See more keywords