Frenolicin B Targets Peroxiredoxin 1 and Glutaredoxin 3 to Trigger ROS/4E-BP1-Mediated Antitumor Effects.
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DOI: 10.1016/j.chembiol.2018.11.013
Abstract: Peroxiredoxin 1 (Prx1) and glutaredoxin 3 (Grx3) are two major antioxidant proteins that play a critical role in maintaining redox homeostasis for tumor progression. Here, we identify the prototypical pyranonaphthoquinone natural product frenolicin B (FB)… read more here.
Keywords: bp1; glutaredoxin; prx1 grx3; frenolicin targets ... See more keywords