Exploring Receptor Binding Affinities and Hepatic Cell Association of N-Acetyl-d-Galactosamine-Modified β-Cyclodextrin-Based Polyrotaxanes for Liver-Targeted Therapies.
Sign Up to like & getrecommendations! Published in 2023 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.3c00194
Abstract: Acid-degradable polyrotaxanes (PRXs) containing threading β-cyclodextrins (β-CDs) are promising candidates for therapeutic applications of β-CDs in metabolic diseases with cholesterol overload or imbalance. To improve cellular uptake specificity and efficiency of PRXs in hepatocytes, N-acetyl-d-galactosamine… read more here.
Keywords: binding affinity; galnac prxs; number; acetyl galactosamine ... See more keywords
Acid-Induced Intracellular Dissociation of β-Cyclodextrin-Threaded Polyrotaxanes Directed toward Attenuating Phototoxicity of Bisretinoids through Promoting Excretion.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b00859
Abstract: In the retinal pigment epithelium of patients with age-related macular degeneration (AMD), excess N-retinylidene-N-retinylethanolamine (A2E), a dimer of all-trans-retinal, accumulats to induce inflammatory cytokine secretion and phototoxic effects. Therefore, the reduction of intracellular A2E is… read more here.
Keywords: threaded polyrotaxanes; cyclodextrin threaded; acid labile; prxs ... See more keywords
Active-site plasticity revealed in the asymmetric dimer of AnPrx6 the 1-Cys peroxiredoxin and molecular chaperone from Anabaena sp. PCC 7120
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-17044-3
Abstract: Peroxiredoxins (Prxs) are vital regulators of intracellular reactive oxygen species levels in all living organisms. Their activity depends on one or two catalytically active cysteine residues, the peroxidatic Cys (CP) and, if present, the resolving… read more here.
Keywords: cys; anabaena; active site; prxs ... See more keywords
Redox Regulation of PTEN by Peroxiredoxins
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DOI: 10.3390/antiox10020302
Abstract: Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is known as a tumor suppressor gene that is frequently mutated in numerous human cancers and inherited syndromes. PTEN functions as a negative regulator of PI3K/Akt… read more here.
Keywords: prxs; regulation pten; pten peroxiredoxins; redox regulation ... See more keywords
The Role of Peroxiredoxins in Cancer Development
Sign Up to like & getrecommendations! Published in 2023 at "Biology"
DOI: 10.3390/biology12050666
Abstract: Simple Summary Reactive oxygen species (ROS) are unstable derivatives of oxygen that are generated naturally as products or biproducts of biological reactions. ROS, such as hydrogen peroxide, can be utilized for defense against infectious agents… read more here.
Keywords: cancer development; peroxiredoxins cancer; role peroxiredoxins; prxs ... See more keywords