Rab21, a Novel PS1 Interactor, Regulates γ-Secretase Activity via PS1 Subcellular Distribution
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0606-3
Abstract: Abstractγ-Secretase has been a therapeutical target for its key role in cleaving APP to generate β-amyloid (Aβ), the primary constituents of senile plaques and a hallmark of Alzheimer’s disease (AD) pathology. Recently, γ-secretase-associating proteins showed… read more here.
Keywords: ps1; secretase associating; secretase activity; rab21 ... See more keywords
Inhibition of γ-Secretase Leads to an Increase in Presenilin-1
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0705-1
Abstract: Abstractγ-Secretase inhibitors (GSIs) are potential therapeutic agents for Alzheimer’s disease (AD); however, trials have proven disappointing. We addressed the possibility that γ-secretase inhibition can provoke a rebound effect, elevating the levels of the catalytic γ-secretase… read more here.
Keywords: ps1; secretase leads; inhibition; increase ... See more keywords
Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2017.12.009
Abstract: Alzheimer'sdisease(AD) is characterized by deposition of amyloid-β (Aβ)plaques, neurofibrillary tangles, andneuronal loss, accompaniedbyneuroinflammation. Neuroinflammatoryprocesses are thought to contribute toAD pathophysiology. Metformin has been reported to have anti-inflammatory efficacy. However, whether metformin is responsible for the… read more here.
Keywords: ps1; app ps1; metformin; ps1 mice ... See more keywords
Novel Approach of Biophotovoltaic Solid State Solar Cells Based on a Multilayer of PS1 Complexes as an Active Layer
Sign Up to like & getrecommendations! Published in 2017 at "ACS Sustainable Chemistry & Engineering"
DOI: 10.1021/acssuschemeng.7b01699
Abstract: Due to the ever-increasing demand for electrical energy, research on renewable energies has achieved tremendous gains. In this study nature has inspired us by the photosynthetic process and triggered the idea of applying the heart… read more here.
Keywords: ps1; solid state; state solar; active layer ... See more keywords
Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-019-1450-3
Abstract: BackgroundAlzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by an abnormal accumulation of amyloid-β (Aβ) plaques, neuroinflammation, and impaired neurogenesis. Urolithin A (UA), a gut-microbial metabolite of ellagic acid, has been reported to exert… read more here.
Keywords: ps1; neurogenesis; neuroinflammation; ps1 mice ... See more keywords
Elevated cellular cholesterol in Familial Alzheimer’s presenilin 1 mutation is associated with lipid raft localization of β-amyloid precursor protein
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0210535
Abstract: Familial Alzheimer’s disease (FAD)-associated presenilin 1 (PS1) serves as a catalytic subunit of γ-secretase complex, which mediates the proteolytic liberation of β-amyloid (Aβ) from β-amyloid precursor protein (APP). In addition to its proteolytic role, PS1… read more here.
Keywords: ps1; amyloid; familial alzheimer; cholesterol ... See more keywords
Differences in Synaptic Dysfunction Between rTg4510 and APP/PS1 Mouse Models of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Alzheimer's Disease"
DOI: 10.3233/jad-170457
Abstract: Genetically modified mice have provided insights into the progression and pathology of Alzheimer’s disease (AD). Here, we have examined two mouse models of AD: the rTg4510 mouse, which overexpresses mutant human Tau gene, and the… read more here.
Keywords: ps1; pathology; rtg4510; mice ... See more keywords
The Molecular Mechanism of Chronic High-Dose Corticosterone-Induced Aggravation of Cognitive Impairment in APP/PS1 Transgenic Mice
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2020.613421
Abstract: Clinical studies have found that some Alzheimer’s disease (AD) patients suffer from Cushing’s syndrome (CS). CS is caused by the long-term release of excess glucocorticoids (GCs) from the adrenal gland, which in turn, impair brain… read more here.
Keywords: ps1; mechanism; cort; mice ... See more keywords
The role of ADAM17 in cerebrovascular and cognitive function in the APP/PS1 mouse model of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2023.1125932
Abstract: Introduction The disintegrin and metalloproteinase 17 (ADAM17) exhibits α-secretase activity, whereby it can prevent the production of neurotoxic amyloid precursor protein-α (APP). ADAM17 is abundantly expressed in vascular endothelial cells and may act to regulate… read more here.
Keywords: function; app ps1; expression; ps1 ... See more keywords
Integrated untargeted and targeted metabolomics to reveal therapeutic effect and mechanism of Alpiniae oxyphyllae fructus on Alzheimer’s disease in APP/PS1 mice
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1104954
Abstract: Introduction: Alpiniae oxyphyllae Fructus (AOF) has been abundantly utilized for the treatment of diarrhea, dyspepsia, kidney asthenia, and abdominal pain in China. AOF is effective for treating AD in clinical trials, but its exact mode… read more here.
Keywords: alpiniae oxyphyllae; group; bile acids; ps1 ... See more keywords
Partial Endothelial Nitric Oxide Synthase Deficiency Exacerbates Cognitive Deficit and Amyloid Pathology in the APPswe/PS1ΔE9 Mouse Model of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137316
Abstract: Increasing evidence implicates endothelial dysfunction in the pathogenesis of Alzheimer’s disease (AD). Nitric oxide (NO) derived from endothelial NO synthase (eNOS) is essential in maintaining cerebrovascular function and can modulate the production and clearance of… read more here.
Keywords: pathology; ps1; mice; endothelial dysfunction ... See more keywords