Phosphorylated Lamin A/C in the Nuclear Interior Binds Active Enhancers Associated with Abnormal Transcription in Progeria.
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DOI: 10.1016/j.devcel.2020.02.011
Abstract: LMNA encodes nuclear Lamin A/C that tethers lamina-associated domains (LADs) to the nuclear periphery. Mutations in LMNA cause degenerative disorders including the premature aging disorder Hutchinson-Gilford progeria, but the mechanisms are unknown. We report that… read more here.
Keywords: nuclear interior; ps22 lamin; progeria; lamin binding ... See more keywords