Respective roles of the mitogen-activated protein kinase (MAPK) family members in pancreatic stellate cell activation induced by transforming growth factor-β1 (TGF-β1).
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.04.176
Abstract: Activated pancreatic stellate cells (PSCs) play a crucial role in the progression of pancreatic fibrosis. Transforming growth factor-β (TGF-β) is one of the strongest stimulator inducing fibrosis. The mitogen-activated protein kinase (MAPK) proteins (including ERK,… read more here.
Keywords: p38 mapk; psc activation; jnk erk; activation ... See more keywords
Antioxidant Mitoquinone Alleviates Chronic Pancreatitis via Anti-Fibrotic and Antioxidant Effects
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DOI: 10.2147/jir.s357394
Abstract: Background Chronic pancreatitis (CP) is a long-term inflammatory disease of the pancreas that can be caused by various pathogenic factors. Oxidative stress (OS), which is associated with several pancreatic diseases, can induce pancreatic stellate cell… read more here.
Keywords: antioxidant; chronic pancreatitis; psc activation; antioxidant mitoquinone ... See more keywords
Pancreatic Stellate Cells and Metabolic Alteration: Physiology and Pathophysiology
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DOI: 10.3389/fphys.2022.865105
Abstract: Pancreatic stellate cells play a pivotal role in the development of pancreatic fibrosis. A wide variety of external stimuli can cause PSC activation accompanied by metabolic changes, which alters the tissue microenvironment by producing extracellular… read more here.
Keywords: pancreatic stellate; cells metabolic; psc activation; physiology ... See more keywords