Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2016.12.040
Abstract: Pluripotent stem cells (PSCs) offer unprecedented opportunities for disease modeling and personalized medicine. However, PSC-derived cells exhibit fetal-like characteristics and remain immature in a dish. This has emerged as a major obstacle for their application for late-onset… read more here.
Keywords: psc cms; cms; neonatal transplantation; psc derived ... See more keywords
Abstract Thu023: Inter-Organ Comparison Identifies Shared MicroRNAs during Maturation
Sign Up to like & getrecommendations! Published in 2025 at "Circulation Research"
DOI: 10.1161/res.137.suppl_1.thu023
Abstract: Introduction: The immaturity of pluripotent stem cell (PSC)-derived cells remains a major barrier for their application in disease modeling, drug screening, and regenerative medicine. PSC-derived cardiomyocytes (PSC-CMs), in particular, exhibit fetal-like structural and functional properties,… read more here.
Keywords: maturation; heart; psc derived; cell ... See more keywords