Determining the time to cholangiocarcinoma in pediatric-onset PSC-IBD.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of pediatric gastroenterology and nutrition"
DOI: 10.1002/jpn3.12443
Abstract: Primary sclerosing cholangitis (PSC) is a risk factor for cholangiocarcinoma. When a child is diagnosed with both PSC and inflammatory bowel disease (IBD), evidence-based information on counseling families and risk management of developing cholangiocarcinoma is… read more here.
Keywords: pediatric onset; psc ibd; time; cholangiocarcinoma ... See more keywords
Risk of hepato‐pancreato‐biliary cancer is increased by primary sclerosing cholangitis in patients with inflammatory bowel disease: A population‐based cohort study
Sign Up to like & getrecommendations! Published in 2022 at "United European Gastroenterology Journal"
DOI: 10.1002/ueg2.12204
Abstract: Abstract Background There is continued uncertainty regarding the risks of hepato‐pancreato‐biliary cancers in patients with inflammatory bowel disease (IBD) with or without concomitant primary sclerosing cholangitis (PSC). Objective To give updated estimates on risk of… read more here.
Keywords: hepato pancreato; pancreato biliary; psc ibd; ibd patients ... See more keywords
Bile Acids Modulate Colonic MAdCAM-1 Expression in a Murine Model of Combined Cholestasis and Colitis
Sign Up to like & getrecommendations! Published in 2020 at "Mucosal immunology"
DOI: 10.1038/s41385-020-00347-6
Abstract: Primary sclerosing cholangitis (PSC) is a progressive fibrosing cholestatic liver disease that is strongly associated with inflammatory bowel disease (IBD). PSC-associated IBD (PSC-IBD) displays a unique phenotype characterized by right-side predominant colon inflammation and increased… read more here.
Keywords: psc ibd; psc; madcam expression; colitis ... See more keywords
Gut Pathobiont-Derived Outer Membrane Vesicles Drive Liver Inflammation and Fibrosis in PSC-IBD.
Sign Up to like & getrecommendations! Published in 2024 at "Gastroenterology"
DOI: 10.1053/j.gastro.2024.06.032
Abstract: BACKGROUND & AIMS Primary sclerosing cholangitis (PSC), often associated with inflammatory bowel disease (IBD), presents a multifactorial etiology involving genetic, immunological, and environmental factors. Gut dysbiosis and bacterial translocation have been implicated in PSC-IBD, yet… read more here.
Keywords: liver inflammation; psc ibd; fibrosis; ibd ... See more keywords
Genetic Profiling of Colorectal Carcinomas of Patients with Primary Sclerosing Cholangitis and Inflammatory Bowel Disease
Sign Up to like & getrecommendations! Published in 2022 at "Inflammatory Bowel Diseases"
DOI: 10.1093/ibd/izac087
Abstract: Abstract Background Patients with primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) run a 10-fold increased risk of developing colorectal cancer (CRC) compared to patients with IBD only. The aim of this study was… read more here.
Keywords: crc; psc ibd; inflammatory bowel; ibd crc ... See more keywords
Long-term Outcomes Following Colectomy and Liver Transplantation for Inflammatory Bowel Disease with Primary Sclerosing Cholangitis.
Sign Up to like & getrecommendations! Published in 2024 at "Annals of surgery"
DOI: 10.1097/sla.0000000000006533
Abstract: OBJECTIVE To investigate the long-term outcomes of patients with combined primary sclerosing cholangitis/inflammatory bowel disease (PSC-IBD) undergoing both liver transplantation (LT) and total abdominal colectomy (TAC). SUMMARY BACKGROUND DATA The fraction of patients with PSC-IBD… read more here.
Keywords: disease; psc ibd; term outcomes; long term ... See more keywords
Faecal calprotectin is a surrogate marker of biliary inflammation in primary sclerosing cholangitis associated inflammatory bowel disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontline Gastroenterology"
DOI: 10.1136/flgastro-2021-102053
Abstract: Objective Faecal calprotectin (fCAL) is an established marker of intestinal inflammation in inflammatory bowel disease (IBD). Disproportionally high fCAL levels, for the severity of intestinal inflammation, have been previously observed in primary sclerosing cholangitis associated… read more here.
Keywords: psc ibd; inflammation; calprotectin; marker biliary ... See more keywords
Protective function of sclerosing cholangitis on IBD
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DOI: 10.1136/gutjnl-2023-330856
Abstract: Objective There is a strong clinical association between IBD and primary sclerosing cholangitis (PSC), a chronic disease of the liver characterised by biliary inflammation that leads to strictures and fibrosis. Approximately 60%–80% of people with… read more here.
Keywords: psc ibd; ibd; ibd psc; sclerosing cholangitis ... See more keywords