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   Articles with "psd95" as a keyword



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Intravenous administration of Tat-NR2B9c peptide, a PSD95 inhibitor, attenuates reinstatement of cocaine-seeking behavior in rats

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recommendations! Published in 2021 at "Behavioural Brain Research"

DOI: 10.1016/j.bbr.2021.113537

Abstract: Cocaine use disorder is a serious, chronic and relapsing disease of the nervous system, for which effective treatments do not yet exist. Recently, the role of the N-methyl-d-aspartate (NMDA) receptor subunit GluN2B has been highlighted… read more here.

Keywords: psd95; seeking behavior; cocaine seeking; tat nr2b9c ... See more keywords
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Methylation in Syn and Psd95 genes underlie the inhibitory effect of oxytocin on oxycodone-induced conditioned place preference

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recommendations! Published in 2019 at "European Neuropsychopharmacology"

DOI: 10.1016/j.euroneuro.2019.10.010

Abstract: Oxycodone (Oxy) is one of the most effective analgesics in medicine, but is associated with the development of dependence. Recent studies demonstrating epigenetic changes in the brain after exposure to opiates have provided an insight… read more here.

Keywords: psd95; syn psd95; methylation; conditioned place ... See more keywords
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Inhibition of PSD95‐nNOS protein–protein interactions decreases morphine reward and relapse vulnerability in rats

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recommendations! Published in 2022 at "Addiction Biology"

DOI: 10.1111/adb.13220

Abstract: Glutamate signalling through the N‐methyl‐d‐aspartate receptor (NMDAR) activates the enzyme neuronal nitric oxide synthase (nNOS) to produce the signalling molecule nitric oxide (NO). We hypothesized that disruption of the protein–protein interaction between nNOS and the… read more here.

Keywords: protein protein; reward relapse; psd95 nnos; psd95 ... See more keywords

Hierarchical organization and genetically separable subfamilies of PSD95 postsynaptic supercomplexes

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recommendations! Published in 2017 at "Journal of Neurochemistry"

DOI: 10.1111/jnc.14056

Abstract: PSD95 is an abundant postsynaptic scaffold protein in glutamatergic synapses that assembles into supercomplexes composed of over 80 proteins including neurotransmitter receptors, ion channels and adhesion proteins. How these diverse constituents are organized into PSD95… read more here.

Keywords: psd95; hierarchical organization; organization genetically; psd95 supercomplexes ... See more keywords
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Inhibition of the postsynaptic density protein 95 on the protective effect of Ang-(1-7)–Mas on cerebral ischaemia injury

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recommendations! Published in 2022 at "Stroke and Vascular Neurology"

DOI: 10.1136/svn-2021-001396

Abstract: Background Postsynaptic density protein-95 (PSD95) plays an important role in cerebral ischaemia injury, but its mechanism needs further research. This study aimed to explore the role of PSD95 in (Ang-(1-7))-Mas-mediated cerebral ischaemia protection and its… read more here.

Keywords: density protein; postsynaptic density; psd95; ang mas ... See more keywords