Targeting PSD95-nNOS interaction by Tat-N-dimer peptide during status epilepticus is neuroprotective in MAM-pilocarpine rat model
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.04.028
Abstract: Glutamate receptors play a crucial pathogenic role in brain damage induced by status epilepticus (SE). SE may initiate NMDAR-dependent excitotoxicity through the production of oxidative damage mediated by the activation of a ternary complex formed… read more here.
Keywords: pilocarpine; psd95 nnos; mam pilocarpine; pilocarpine rat ... See more keywords
Inhibition of PSD95‐nNOS protein–protein interactions decreases morphine reward and relapse vulnerability in rats
Sign Up to like & getrecommendations! Published in 2022 at "Addiction Biology"
DOI: 10.1111/adb.13220
Abstract: Glutamate signalling through the N‐methyl‐d‐aspartate receptor (NMDAR) activates the enzyme neuronal nitric oxide synthase (nNOS) to produce the signalling molecule nitric oxide (NO). We hypothesized that disruption of the protein–protein interaction between nNOS and the… read more here.
Keywords: protein protein; reward relapse; psd95 nnos; psd95 ... See more keywords