Genetics, Functions, and Clinical Impact of Presenilin-1 (PSEN1) Gene
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DOI: 10.3390/ijms231810970
Abstract: Presenilin-1 (PSEN1) has been verified as an important causative factor for early onset Alzheimer’s disease (EOAD). PSEN1 is a part of γ-secretase, and in addition to amyloid precursor protein (APP) cleavage, it can also affect… read more here.
Keywords: presenilin psen1; psen1; clinical phenotypes; psen1 mutations ... See more keywords
Presenilin-1 (PSEN1) Mutations: Clinical Phenotypes beyond Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24098417
Abstract: Presenilin 1 (PSEN1) is a part of the gamma secretase complex with several interacting substrates, including amyloid precursor protein (APP), Notch, adhesion proteins and beta catenin. PSEN1 has been extensively studied in neurodegeneration, and more… read more here.
Keywords: presenilin psen1; psen1; disease; alzheimer disease ... See more keywords