Total Synthesis of Pseudellone C
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DOI: 10.1002/ejoc.201700491
Abstract: The first chemical synthesis of a bisindole alkaloid, pseudellone C, was achieved in 44 % overall yield. The highlighting features of the synthesis include the fact that it is protecting-group free, economic and commercially available starting… read more here.
Keywords: pseudellone; chemistry; total synthesis; synthesis pseudellone ... See more keywords
Synthesis of Pseudellone Analogs and Characterization as Novel T-type Calcium Channel Blockers
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DOI: 10.3390/md16120475
Abstract: T-type calcium channel (CaV3.x) blockers are receiving increasing attention as potential therapeutics for the treatment of pathophysiological disorders and diseases, including absence epilepsy, Parkinson’s disease (PD), hypertension, cardiovascular diseases, cancers, and pain. However, few clinically… read more here.
Keywords: pseudellone; calcium channel; type calcium; ic50 ... See more keywords