Discovery of a Novel Pseudo‐Natural Product Aurora Kinase Inhibitor Chemotype through Morphological Profiling
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202309202
Abstract: The pseudo‐natural product (pseudo‐NP) concept aims to combine NP fragments in arrangements that are not accessible through known biosynthetic pathways. The resulting compounds retain the biological relevance of NPs but are not yet linked to… read more here.
Keywords: natural product; morphological profiling; aurora kinase; kinase ... See more keywords
Pseudo‐Natural Products Inspired by Aspidospermidine‐, Strychnos‐, and Koumine Monoterpene Indole Alkaloids Reveal Pyrimidine Biosynthesis Inhibitors
Sign Up to like & getrecommendations! Published in 2025 at "Helvetica Chimica Acta"
DOI: 10.1002/hlca.202500155
Abstract: In pseudo‐natural product (PNP) design, natural product fragments are combined in arrangements not found in nature to afford novel biologically relevant NP‐related compound classes. A pseudo‐natural product compound collection inspired by aspidospermidine‐, strychnos‐, and koumine… read more here.
Keywords: natural product; koumine monoterpene; aspidospermidine strychnos; pseudo natural ... See more keywords
Enantioselective synthesis of pyrro[3,4-c]quinoline pseudo-natural products
Sign Up to like & getrecommendations! Published in 2021 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2021.153228
Abstract: Abstract Pseudo natural products (PNPs) are natural product-inspired compounds obtained by unprecedented combination of natural product (NP) fragments in complexity-generating transformations. The pyrrolidine- and tetrahydroquinoline fragments individually occur in numerous NPs with diverse bioactivity, yet… read more here.
Keywords: natural products; pseudo natural; quinoline pseudo; synthesis pyrro ... See more keywords
Machine Learning-Guided Generation of Novel Pseudo-Natural Products: Applications to Accelerate Drug Discovery.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.5c01955
Abstract: Natural products (NPs) are a critical source for drug discovery, and artificial intelligence (AI) is utilized to improve the efficiency of NP-based drug discovery. However, the existing AI-driven models typically generate a library of pseudo-natural… read more here.
Keywords: natural products; machine learning; drug discovery; drug ... See more keywords
De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c07937
Abstract: Bioengineering of ribosomally synthesized and post-translationally modified peptides (RiPPs) is an emerging approach to explore the diversity of pseudo-natural product structures for drug discovery purposes. However, despite the initial advances in this area, bioactivity reprogramming… read more here.
Keywords: novo discovery; natural products; pseudo natural; kinase ... See more keywords
A divergent intermediate strategy yields biologically diverse pseudo-natural products
Sign Up to like & getrecommendations! Published in 2024 at "Nature Chemistry"
DOI: 10.1038/s41557-024-01458-4
Abstract: The efficient exploration of biologically relevant chemical space is essential for the discovery of bioactive compounds. A molecular design principle that possesses both biological relevance and structural diversity may more efficiently lead to compound collections… read more here.
Keywords: pnp; divergent intermediate; strategy; diverse pseudo ... See more keywords
Synthesis of Diarylpyrrole Pseudo-Natural Products: Cyanide-Mediated Nitrile-to-Nitrile Cyclocondensation and C–H Acidity-Guided Regioselectivity
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DOI: 10.1055/a-2370-6900
Abstract: Pseudo-natural products (pseudo-NPs), the chemically reengineered molecular skeletons generated by the deconstruction of NPs into fragments and their subsequent recombination, have gained immense attention in recent times owing to their ability to occupy a significant… read more here.
Keywords: mediated nitrile; natural products; nitrile nitrile; diarylpyrrole pseudo ... See more keywords
Pseudo-natural products as next-generation scaffolds: redefining the future of medicinal chemistry.
Sign Up to like & getrecommendations! Published in 2025 at "Future medicinal chemistry"
DOI: 10.1080/17568919.2025.2587564
Abstract: Natural products (NPs) have long provided privileged scaffolds for drug discovery, yet their biosynthetic restrictions limit exploration of broader natural product chemical space. Pseudo-natural products (pseudo-NPs) have emerged as a promising strategy to overcome these… read more here.
Keywords: chemistry; next generation; future medicinal; natural products ... See more keywords