Enantioselective synthesis of pyrro[3,4-c]quinoline pseudo-natural products
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DOI: 10.1016/j.tetlet.2021.153228
Abstract: Abstract Pseudo natural products (PNPs) are natural product-inspired compounds obtained by unprecedented combination of natural product (NP) fragments in complexity-generating transformations. The pyrrolidine- and tetrahydroquinoline fragments individually occur in numerous NPs with diverse bioactivity, yet… read more here.
Keywords: natural products; pseudo natural; quinoline pseudo; synthesis pyrro ... See more keywords
De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c07937
Abstract: Bioengineering of ribosomally synthesized and post-translationally modified peptides (RiPPs) is an emerging approach to explore the diversity of pseudo-natural product structures for drug discovery purposes. However, despite the initial advances in this area, bioactivity reprogramming… read more here.
Keywords: novo discovery; natural products; pseudo natural; kinase ... See more keywords