Generation and CRISPR/Cas9 editing of transformed progenitor B cells as a pseudo-physiological system to study DNA repair gene function in V(D)J recombination
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DOI: 10.1016/j.jim.2017.08.007
Abstract: Antigen receptor gene assembly is accomplished in developing lymphocytes by the V(D)J recombination reaction, which can be separated into two steps: DNA cleavage by the recombination-activating gene (RAG) nuclease and joining of DNA double strand… read more here.
Keywords: pseudo physiological; system study; recombination; cell ... See more keywords