GENCODE Pseudogenes.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1503-4_5
Abstract: Pseudogenes have long been considered nonfunctional elements. The influx of large-scale sequencing projects over the last decade have provided rich sources of evidence that pseudogenes can play key evolutionary and regulatory roles, highlighting the need… read more here.
Keywords: pseudogene; gencode pseudogenes; biology;
NDUFV2 pseudogene (NDUFV2P1) contributes to mitochondrial complex I deficits in schizophrenia
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Psychiatry"
DOI: 10.1038/s41380-018-0309-9
Abstract: Mitochondria together with other cellular components maintain a constant crosstalk, modulating transcriptional and posttranslational processes. We and others demonstrated mitochondrial multifaceted dysfunction in schizophrenia, with aberrant complex I (CoI) as a major cause. Here we… read more here.
Keywords: schizophrenia; pseudogene; ndufv2 pseudogene; coi ... See more keywords
Segmental Variation in a Duplicated msp2 Pseudogene Generates Anaplasma marginale Antigenic Variants
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DOI: 10.1128/iai.00727-18
Abstract: Anaplasma marginale is a prototypical highly antigenically variant bacterial pathogen dependent on the sequential generation of major surface protein 2 (Msp2) outer membrane variants to establish persistent infection. Msp2 is encoded by a single expression… read more here.
Keywords: pseudogene; anaplasma marginale; antigenic variants; msp2 pseudogene ... See more keywords
Deletion of a pseudogene within a fragile site triggers the oncogenic expression of the mitotic CCSER1 gene
Sign Up to like & getrecommendations! Published in 2021 at "Life Science Alliance"
DOI: 10.26508/lsa.202101019
Abstract: Frequent deletions impacting the FRA4F fragile site leads to the oncogenic overexpression of the corresponding CCSER1 gene, through the deletion of the TMSB4XP8 pseudogene. The ensuing CCSER1 overexpression elicits mitotic instability, targetable with aurora kinase… read more here.
Keywords: ccser1 gene; gene; pseudogene; fragile site ... See more keywords
Exploration of shared TF-miRNA‒mRNA and mRNA-RBP-pseudogene networks in type 2 diabetes mellitus and breast cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.915017
Abstract: Type 2 diabetes mellitus (T2DM) has been confirmed to be closely associated with breast cancer (BC). However, the shared mechanisms between these diseases remain unclear. By comparing different datasets, we identified shared differentially expressed (DE)… read more here.
Keywords: pseudogene; mirna mrna; mrna; breast cancer ... See more keywords
Functional Characterization of a Phf8 Processed Pseudogene in the Mouse Genome
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DOI: 10.3390/genes14010172
Abstract: The majority of pseudogenes are generated when an RNA transcript is reverse-transcribed and integrated into the genome at a new location. Pseudogenes are often considered as an imperfect and silent copy of a functional gene… read more here.
Keywords: pseudogene; phf8; mouse genome; pseudogene mouse ... See more keywords