Dealing with Pseudogenes in Molecular Diagnostics in the Next Generation Sequencing Era.
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DOI: 10.1007/978-1-0716-1503-4_22
Abstract: Presence of pseudogenes is a dreadful issue in next generation sequencing (NGS), because their contamination can interfere with the detection of variants in the genuine gene and generate false positive and false negative variants.In this… read more here.
Keywords: pseudogenes molecular; dealing pseudogenes; next generation; molecular diagnostics ... See more keywords
Re-recognition of pseudogenes: From molecular to clinical applications
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DOI: 10.7150/thno.40659
Abstract: Pseudogenes were initially regarded as “nonfunctional” genomic elements that did not have protein-coding abilities due to several endogenous inactivating mutations. Although pseudogenes are widely expressed in prokaryotes and eukaryotes, for decades, they have been largely… read more here.
Keywords: recognition pseudogenes; molecular clinical; pseudogenes molecular; disease ... See more keywords