Synthetic studies on pseudolaric acid B: Enantioselective synthesis of C4,C10-di-epi-trans-fused [5-7]-bicyclic skeleton
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2020.09.023
Abstract: Abstract Studies on the synthesis of antifungal and anticancer natural product, pseudolaric acid B, have led to the enantioselective synthesis of di-epi-trans-fused [5–7]-bicyclic core skeleton. The synthesis was achieved in 10 linear steps, which features… read more here.
Keywords: synthesis; epi trans; pseudolaric acid; fused bicyclic ... See more keywords
Pseudolaric Acid B Ameliorates Fungal Keratitis Progression by Suppressing Inflammation and Reducing Fungal Load.
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DOI: 10.1021/acsinfecdis.2c00536
Abstract: This study aimed to determine the mechanisms of antifungal and anti-inflammation effects of pseudolaric acid B (PAB) on Aspergillus fumigatus (A. fumigatus) keratitis. In vitro MIC assay and crystal violet staining were conducted to evaluate… read more here.
Keywords: inflammation; keratitis; fumigatus; pab ... See more keywords
Chemical proteomics reveal CD147 as a functional target of pseudolaric acid B in human cancer cells.
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DOI: 10.1039/c7cc04345g
Abstract: CD147 is a glycosylated transmembrane protein highly expressed on the surface of various tumor cells which plays vital roles in tumor invasion, progression and metastasis. We report the discovery of the natural product pseudolaric acid… read more here.
Keywords: reveal cd147; pseudolaric acid; functional target; chemical proteomics ... See more keywords