Burkholderia pseudomallei acquired ceftazidime resistance due to gene duplication and amplification.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2019.01.003
Abstract: Ceftazidime (CAZ) is the antibiotic of choice for the treatment of Burkholderia pseudomallei infection (melioidosis). The chromosomally-encoded PenA β-lactamase possesses weak cephalosporinase activity. The wild-type penA gene confers clinically significant CAZ resistance only when overexpressed… read more here.
Keywords: gene duplication; resistance; pseudomallei; gene ... See more keywords
Phylogenetic Diversity of Burkholderia pseudomallei isolated from veterinary cases and the environments in Peninsular Malaysia
Sign Up to like & getrecommendations! Published in 2018 at "Veterinary and Animal Science"
DOI: 10.1016/j.vas.2018.07.004
Abstract: This study was designed to determine the genotype and the phylogeny of Burkholderia pseudomallei isolated from veterinary cases and from the animal environments in Peninsular Malaysia. The Malaysian B. pseudomallei population were then compared to… read more here.
Keywords: malaysia; pseudomallei isolated; veterinary cases; pseudomallei ... See more keywords
D-LL-31 in combination with ceftazidime synergistically enhances bactericidal activity and biofilm destruction in Burkholderia pseudomallei
Sign Up to like & getrecommendations! Published in 2019 at "Biofouling"
DOI: 10.1080/08927014.2019.1632835
Abstract: Abstract Melioidosis is a severe disease caused by Burkholderia pseudomallei. The biofilm of B. pseudomallei acquires resistance to several antibiotics and may be related to relapse in melioidosis patients. Here, the killing activity of antimicrobial… read more here.
Keywords: burkholderia pseudomallei; ceftazidime synergistically; biofilm; pseudomallei ... See more keywords
Pathogenicity and virulence of Burkholderia pseudomallei
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DOI: 10.1080/21505594.2022.2139063
Abstract: ABSTRACT The soil saprophyte, Burkholderia pseudomallei, is the causative agent of melioidosis, a disease endemic in South East Asia and northern Australia. Exposure to B. pseudomallei by either inhalation or inoculation can lead to severe… read more here.
Keywords: cell; pseudomallei; burkholderia pseudomallei; virulence ... See more keywords
Validation of a Lateral Flow Test for the Presumptive Identification of the Presence of Burkholderia mallei or Burkholderia pseudomallei in Environmental Samples.
Sign Up to like & getrecommendations! Published in 2022 at "Health security"
DOI: 10.1089/hs.2021.0168
Abstract: We conducted a comprehensive, multiphase laboratory evaluation of InBios Active Melioidosis Detect (AMD) rapid test, a lateral flow immunoassay designed to detect capsular polysaccharides produced by Burkholderia mallei or Burkholderia pseudomallei, used in conjunction with… read more here.
Keywords: lateral flow; pseudomallei; test; burkholderia mallei ... See more keywords
Finafloxacin overcomes Burkholderia pseudomallei efflux-mediated fluoroquinolone resistance
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DOI: 10.1093/jac/dkw529
Abstract: Sir, Burkholderia pseudomallei is a biothreat agent and causes melioidosis, a globally emerging infectious disease with high case fatality rates, and B. pseudomallei infections are difficult to treat. Although curiously rare in B. pseudomallei, drug… read more here.
Keywords: finafloxacin; bpeef oprc; resistance; pseudomallei ... See more keywords
Epidemiological and Clinical Characteristics of Melioidosis Caused by Gentamicin-Susceptible Burkholderia pseudomallei in Sarawak, Malaysia
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DOI: 10.1093/ofid/ofab460
Abstract: Abstract Background Burkholderia pseudomallei, the causative agent of melioidosis, is intrinsically resistant to a broad range of antibiotics, including aminoglycosides. In Sarawak, Malaysia, a high proportion of melioidosis cases are caused by gentamicin-susceptible isolates. There… read more here.
Keywords: gentamicin susceptible; pseudomallei; sarawak malaysia; melioidosis ... See more keywords
Misidentification of Burkholderia pseudomallei as Acinetobacter species in northern Thailand
Sign Up to like & getrecommendations! Published in 2019 at "Transactions of the Royal Society of Tropical Medicine and Hygiene"
DOI: 10.1093/trstmh/try108
Abstract: Abstract Background Burkholderia pseudomallei is the causative agent of melioidosis, a disease endemic throughout the tropics. Methods A study of reported Acinetobacter spp. bacteraemia was performed at Chiang Rai provincial hospital from 2014 to 2015.… read more here.
Keywords: acinetobacter spp; pseudomallei; misidentification burkholderia; burkholderia pseudomallei ... See more keywords
Melioidosis and Burkholderia pseudomallei: progress in epidemiology, diagnosis, treatment and vaccination
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DOI: 10.1097/qco.0000000000000869
Abstract: Purpose of review Melioidosis and its causative bacterium Burkholderia pseudomallei are being found in unexpected locations and bacterial genotyping is providing new insights into global spread and where and how individuals are being infected. This… read more here.
Keywords: pseudomallei; diagnosis treatment; epidemiology; melioidosis ... See more keywords
Demonstrating the Protective Efficacy of the Novel Fluoroquinolone Finafloxacin against an Inhalational Exposure to Burkholderia pseudomallei
Sign Up to like & getrecommendations! Published in 2017 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00082-17
Abstract: ABSTRACT Burkholderia pseudomallei is the causative agent of melioidosis, a serious disease endemic in Southeast Asia and Northern Australia. Antibiotic treatment is lengthy and relapse often occurs. Finafloxacin is a novel fluoroquinolone with increased antibacterial… read more here.
Keywords: novel fluoroquinolone; burkholderia pseudomallei; pseudomallei; efficacy ... See more keywords
Using Land Runoff To Survey the Distribution and Genetic Diversity of Burkholderia pseudomallei Strains in Vientiane, Laos
Sign Up to like & getrecommendations! Published in 2020 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.02112-20
Abstract: The environmental bacterium B. pseudomallei is the etiological agent of melioidosis, a tropical disease with one model estimating a global annual incidence of 165,000 cases and 89,000 deaths. In the Lao People’s Democratic Republic (Laos),… read more here.
Keywords: pseudomallei; bacterium pseudomallei; laos; runoff ... See more keywords