Structures of the N‐Terminal Domain of PqsA in Complex with Anthraniloyl‐ and 6‐Fluoroanthraniloyl‐AMP: Substrate Activation in Pseudomonas Quinolone Signal (PQS) Biosynthesis
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DOI: 10.1002/cbic.201700374
Abstract: Pseudomonas aeruginosa, a prevalent pathogen in nosocomial infections and a major burden in cystic fibrosis, uses three interconnected quorum‐sensing systems to coordinate virulence processes. At variance with other Gram‐negative bacteria, one of these systems relies… read more here.
Keywords: pqs; pseudomonas quinolone; amp; pqsa ... See more keywords
An Immunochemical Approach to Quantify and Assess the Potential Value of the Pseudomonas Quinolone Signal as a Biomarker of Infection
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DOI: 10.1021/acs.analchem.0c04731
Abstract: Quorum sensing (QS) is a bacterial cell density-based communication system using low molecular weight signals called autoinducers (AIs). Identification and quantification of these molecules could provide valuable information related to the stage of colonization or… read more here.
Keywords: pseudomonas quinolone; infection; disease; quinolone signal ... See more keywords
Structural basis for recognition and ring-cleavage of the Pseudomonas quinolone signal (PQS) by AqDC
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Structural Biology"
DOI: 10.2210/pdb6ra2/pdb
Abstract: Abstract The cofactor-less dioxygenase AqdC of Mycobacteroides abscessus catalyzes the cleavage and thus inactivation of the Pseudomonas quinolone signal (PQS, 2-heptyl-3-hydroxy-4(1H)-quinolone), which plays a central role in the regulation of virulence factor production by Pseudomonas… read more here.
Keywords: aqdc; pqs; cleavage; signal pqs ... See more keywords