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   Articles with "pseudouridylation" as a keyword



Pseudouridylation of 7SK by PUS7 regulates Pol II transcription elongation

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-64668-5

Abstract: Pseudouridine (Ψ) is a widespread RNA modification in various RNA species, including rRNA, tRNA, snRNA and mRNA. Ψ plays a crucial role in RNA metabolism, where it regulates pre-mRNA splicing and affects protein translation. Whether… read more here.

Keywords: pseudouridylation 7sk; transcription elongation; pseudouridylation; rna ... See more keywords

Mechanistic insight into the pseudouridylation of RNA.

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recommendations! Published in 2025 at "RNA biology"

DOI: 10.1080/15476286.2025.2541421

Abstract: ABSTRACT Pseudouridylation (Ψ) is a highly abundant and conserved RNA modification that is present in all three domains of life. The incorporation of Ψ can affect the stability of RNAs, modulate their interaction patterns, and… read more here.

Keywords: pseudouridylation; biology; pseudouridylation rna; mechanistic insight ... See more keywords

A systematic dissection of determinants and consequences of snoRNA-guided pseudouridylation of human mRNA

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recommendations! Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac347

Abstract: Abstract RNA can be extensively modified post-transcriptionally with >170 covalent modifications, expanding its functional and structural repertoire. Pseudouridine (Ψ), the most abundant modified nucleoside in rRNA and tRNA, has recently been found within mRNA molecules.… read more here.

Keywords: systematic dissection; snorna guided; determinants consequences; pseudouridylation ... See more keywords

SNORA70E promotes the occurrence and development of ovarian cancer through pseudouridylation modification of RAP1B and alternative splicing of PARPBP

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recommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.17540

Abstract: The present study demonstrated for the first time that SNORA70E, which belongs to box H/ACA small nucleolar noncoding RNAs (snoRNAs) who could bind and induce pseudouridylation of RNAs, was significantly elevated in ovarian cancer tissues… read more here.

Keywords: rap1b; ovarian cancer; alternative splicing; pseudouridylation ... See more keywords

DKC1-mediated pseudouridylation of rRNA targets hnRNP A1 to sustain IRES-dependent translation and ATF4-driven metabolic adaptation

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recommendations! Published in 2025 at "Science Advances"

DOI: 10.1126/sciadv.adv9401

Abstract: The pseudouridine synthase DKC1 regulates internal ribosome entry site (IRES)–dependent translation and is up-regulated in cancers by the MYC family of oncogenes. The functional significance of DKC1 up-regulation and the mechanistic connection between pseudouridylation and… read more here.

Keywords: ires dependent; dependent translation; pseudouridylation; dkc1 ... See more keywords
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Regulation and Function of RNA Pseudouridylation in Human Cells.

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recommendations! Published in 2020 at "Annual review of genetics"

DOI: 10.1146/annurev-genet-112618-043830

Abstract: Recent advances in pseudouridine detection reveal a complex pseudouridine landscape that includes messenger RNA and diverse classes of noncoding RNA in human cells. The known molecular functions of pseudouridine, which include stabilizing RNA conformations and… read more here.

Keywords: pseudouridylation; genetics; rna pseudouridylation; function rna ... See more keywords

Abstract 280: Targeting mRNA pseudouridylation to suppress neuroblastoma metabolism

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-280

Abstract: Pseudouridylation of mRNA is a common epigenetic modification that reduces RNA conformational flexibility and increases its structural stability and may increase its availability for translation. RNA pseudouridylation is catalyzed by the family of pseudouridine synthases,… read more here.

Keywords: metabolism; mrna pseudouridylation; pseudouridylation; targeting mrna ... See more keywords

Targeted pseudouridylation: An approach for suppressing nonsense mutations in disease genes.

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recommendations! Published in 2023 at "Molecular cell"

DOI: 10.2139/ssrn.3988395

Abstract: Nonsense mutations create premature termination codons (PTCs), activating the nonsense-mediated mRNA decay (NMD) pathway to degrade most PTC-containing mRNAs. The undegraded mRNA is translated, but translation terminates at the PTC, leading to no production of… read more here.

Keywords: pseudouridylation approach; pseudouridylation; nonsense mutations; suppression ... See more keywords

A five-pseudouridylation-associated-LncRNA classifier for primary prostate cancer prognosis prediction

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recommendations! Published in 2023 at "Frontiers in Genetics"

DOI: 10.3389/fgene.2022.1110799

Abstract: Background: Prostate cancer (PCa) is one of the most common cancers in males around the globe, and about one-third of patients with localized PCa will experience biochemical recurrence (BCR) after radical prostatectomy or radiation therapy.… read more here.

Keywords: prostate cancer; lnc score; pca; pseudouridylation ... See more keywords

Turning Uridines around: Role of rRNA Pseudouridylation in Ribosome Biogenesis and Ribosomal Function

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recommendations! Published in 2018 at "Biomolecules"

DOI: 10.3390/biom8020038

Abstract: Ribosomal RNA (rRNA) is extensively edited through base methylation and acetylation, 2′-O-ribose methylation and uridine isomerization. In human rRNA, 95 uridines are predicted to by modified to pseudouridine by ribonucleoprotein complexes sharing four core proteins… read more here.

Keywords: turning uridines; rrna; pseudouridylation; around role ... See more keywords

A Tool to Design Bridging Oligos Used to Detect Pseudouridylation Sites on RNA after CMC Treatment

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recommendations! Published in 2022 at "Non-Coding RNA"

DOI: 10.3390/ncrna8050063

Abstract: Pseudouridylation is one of the most abundant modifications found in RNAs. To identify the Pseudouridylation sites (Psi) in RNAs, several techniques have been developed, but the most common and robust is the CMC (N-cyclohexyl-N′-(2-morpholinoethyl)carbodiimide) treatment,… read more here.

Keywords: design bridging; pseudouridylation sites; pseudouridylation; design ... See more keywords