P-selectin blockade in COVID-19-related ARDS
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Physiology - Lung Cellular and Molecular Physiology"
DOI: 10.1152/ajplung.00202.2020
Abstract: TO THE EDITOR: Many patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop a syndrome that fulfills the Berlin definition for the acute respiratory distress syndrome (ARDS) characterized by very high mortality (14).… read more here.
Keywords: covid related; related ards; psgl; covid ... See more keywords
PSGL-1 Inhibits the Incorporation of SARS-CoV and SARS-CoV-2 Spike Glycoproteins into Pseudovirions and Impairs Pseudovirus Attachment and Infectivity
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DOI: 10.3390/v13010046
Abstract: P-selectin glycoprotein ligand-1 (PSGL-1) is a cell surface glycoprotein that binds to P-, E-, and L-selectins to mediate the tethering and rolling of immune cells on the surface of the endothelium for cell migration into… read more here.
Keywords: cov sars; incorporation sars; psgl; cov spike ... See more keywords
Platelets promote CRC by activating the C5a/C5aR1 axis via PSGL-1/JNK/STAT1 signaling in tumor-associated macrophages
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DOI: 10.7150/thno.80555
Abstract: Rationale: Platelets can influence the progression and prognosis of colorectal cancer (CRC) through multiple mechanisms, including crosstalk with tumor-associated macrophages (TAMs). However, the mechanisms underlying the crosstalk between platelets and TAMs remain unclear. The present… read more here.
Keywords: c5ar1; c5a; crc; jnk ... See more keywords