Synthesis of a β‐d‐Psicofuranosyl Sulfone and Inhibitory‐Activity Evaluation Against N‐Acetylglucosaminyltransferase I
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DOI: 10.1002/ejoc.201701102
Abstract: Alkyl or aryl 3-acetamido-3-deoxy-2-thio-β-d-psicofuranosides bearing a phosphate group at C-1, which were originally designed as potential GnT-I inhibitors (GnT = N-acetylglucosaminyltransferase) by computational methods, were found to be unstable. Therefore their structure was slightly modified… read more here.
Keywords: inhibitor; psicofuranosyl; psicofuranosyl sulfone; inhibitory activity ... See more keywords