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   Articles with "psilocin" as a keyword



Assessment of Bioactivity‐Modulating Pseudo‐Ring Formation in Psilocin and Related Tryptamines

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recommendations! Published in 2022 at "Chembiochem"

DOI: 10.1002/cbic.202200183

Abstract: Psilocybin (1) is the major alkaloid found in psychedelic mushrooms and acts as a prodrug to psilocin (2, 4‐hydroxy‐N,N‐dimethyltryptamine), a potent psychedelic that exerts remarkable alteration of human consciousness. In contrast, the positional isomer bufotenin… read more here.

Keywords: psilocin; pharmacology; assessment bioactivity; ring formation ... See more keywords

Clinical Pharmacokinetics of Psilocin After Psilocybin Administration: A Systematic Review and Post-Hoc Analysis

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recommendations! Published in 2025 at "Clinical Pharmacokinetics"

DOI: 10.1007/s40262-024-01454-4

Abstract: Psilocybin is currently being extensively studied as a potential therapeutic agent for multiple psychiatric disorders. Here, a systematic literature review of all published pharmacokinetic data on the pharmacologically active metabolite of psilocybin, psilocin, is presented.… read more here.

Keywords: psilocybin administration; review; psilocin; clinical pharmacokinetics ... See more keywords

Synthesis and In Vitro Profiling of Psilocin Derivatives: Improved Stability and Synthetic Properties

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recommendations! Published in 2025 at "Journal of Medicinal Chemistry"

DOI: 10.1021/acs.jmedchem.4c02612

Abstract: As interest in using psilocybin therapy for treating mental health disorders intensifies, the need for efficient production methods becomes increasingly important. Current medical-grade psilocybin production is inefficient and relies on a complicated multistep synthesis. This… read more here.

Keywords: psilocin ester; stability; psilocin; ester prodrugs ... See more keywords

Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels

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recommendations! Published in 2019 at "Neuropsychopharmacology"

DOI: 10.1038/s41386-019-0324-9

Abstract: The main psychedelic component of magic mushrooms is psilocybin, which shows promise as a treatment for depression and other mental disorders. Psychedelic effects are believed to emerge through stimulation of serotonin 2A receptors (5-HT2ARs) by… read more here.

Keywords: plasma psilocin; psilocin; ht2ar occupancy; occupancy ... See more keywords