Percentage of Heavy Drinking Days Following Psilocybin-Assisted Psychotherapy vs Placebo in the Treatment of Adult Patients With Alcohol Use Disorder
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Psychiatry"
DOI: 10.1001/jamapsychiatry.2022.2096
Abstract: Key Points Question Does psilocybin-assisted treatment improve drinking outcomes in patients with alcohol use disorder relative to outcomes observed with active placebo medication? Findings In this double-blind randomized clinical trial with 93 participants, the percentage… read more here.
Keywords: psilocybin; percentage heavy; placebo; drinking days ... See more keywords
Psilocybin Outside the Clinic: Public Health Challenges of Increasing Publicity, Accessibility, and Use.
Sign Up to like & getrecommendations! Published in 2025 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2025.3038
Abstract: Importance Psilocybin use has surged in the US following decriminalization efforts and promising clinical trial results. Mirroring early cannabis legalization, public access and enthusiasm are outpacing regulatory oversight and scientific understanding, posing potential risks to… read more here.
Keywords: public health; use; psilocybin outside; psilocybin ... See more keywords
P300‐mediated modulations in self–other processing under psychedelic psilocybin are related to connectedness and changed meaning: A window into the self–other overlap
Sign Up to like & getrecommendations! Published in 2020 at "Human Brain Mapping"
DOI: 10.1002/hbm.25174
Abstract: The concept of self and self‐referential processing has a growing explanatory value in psychiatry and neuroscience, referring to the cognitive organization and perceptual differentiation of self‐stimuli in health and disease. Conditions in which selfhood loses… read more here.
Keywords: changed meaning; time; psilocybin; self ... See more keywords
Incremental efficacy systematic review and meta-analysis of psilocybin-for-depression RCTs
Sign Up to like & getrecommendations! Published in 2025 at "Psychopharmacology"
DOI: 10.1007/s00213-025-06788-w
Abstract: Psilocybin is a potentially paradigm-shifting depression intervention. We conducted a systematic review and meta-analysis of psilocybin-for-depression randomized controlled trials (RCTs). Systematically assess harm reporting, risk of bias, action mechanism specification, and incremental therapeutic effect sizes… read more here.
Keywords: meta analysis; systematic review; psilocybin depression; depression ... See more keywords
Diversity, biology, and history of psilocybin-containing fungi: Suggestions for research and technological development.
Sign Up to like & getrecommendations! Published in 2022 at "Fungal biology"
DOI: 10.1016/j.funbio.2022.01.003
Abstract: Therapeutic use of psilocybin has become a focus of recent international research, with preliminary data showing promise to address a range of treatment-resistant mental health conditions. However, use of psilocybin as a healing entheogen has… read more here.
Keywords: psilocybin containing; history; containing fungi; psilocybin ... See more keywords
DARK Classics in Chemical Neuroscience: Psilocybin.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.8b00186
Abstract: Psilocybin is found in a family of mushrooms commonly known as "magic mushrooms" that have been used throughout history to induce hallucinations. In the late 1950s Albert Hofmann, of Sandoz Laboratories, identified and synthesized the… read more here.
Keywords: dark classics; chemical neuroscience; classics chemical; psilocybin ... See more keywords
Psilocybin: Characterization of the Metastable Zone Width (MSZW), Control of Anhydrous Polymorphs, and Particle Size Distribution (PSD)
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.1c06708
Abstract: Psilocybin, a serotonergic agonist, was granted a “breakthrough therapy” status by the Food and Drug Administration for clinical trials involving major depressive disorder and treatment-resistant depression. The direct phosphorylation of psilocin to psilocybin that uses… read more here.
Keywords: psilocybin; particle; particle size; size distribution ... See more keywords
Structural basis for psilocybin biosynthesis
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-58239-x
Abstract: Psilocybin shows significant therapeutic potential for psilocybin-assisted psychotherapy in addressing various psychiatric conditions. The biosynthetic approach promises rapid and efficient production of psilocybin. Understanding the enzymes that contribute to the biosynthesis of psilocybin can enhance… read more here.
Keywords: basis psilocybin; structural basis; biosynthesis; psilocybin ... See more keywords
Psilocybin during the postpartum period induces long-lasting adverse effects in both mothers and offspring
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-64371-5
Abstract: Psilocybin increases social connectedness and has strong clinical transdiagnostic efficacy for mental illness, making it a candidate treatment to reduce maternal disconnect, anxiety, and blunted affect seen in peripartum mood disorders. However, the efficacy and… read more here.
Keywords: psilocybin postpartum; mothers offspring; psilocybin; postpartum period ... See more keywords
Psilocybin-assisted therapy and HIV-related shame
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-68908-4
Abstract: As a proposed mediator between stigma-related stressors and negative mental health outcomes, HIV-related shame has been predictive of increased rates of substance use and difficulties adhering to antiretroviral treatment among people with HIV. These downstream… read more here.
Keywords: hiv related; related shame; therapy; psilocybin ... See more keywords
An Improved, Practical, and Scalable Five-Step Synthesis of Psilocybin
Sign Up to like & getrecommendations! Published in 2020 at "Synthesis"
DOI: 10.1055/s-0039-1691565
Abstract: Described herein is an improved synthesis of 3-[2-(dimethylamino)ethyl]-1H-indol-4-yl dihydrogen phosphate (psilocybin). The protocol outlines: synthesis of multigram quantities of psilocybin, identification of critical in-process parameters, and isolation of psilocybin without the use of chromatography, TLC,… read more here.
Keywords: five step; scalable five; psilocybin; practical scalable ... See more keywords