Percentage of Heavy Drinking Days Following Psilocybin-Assisted Psychotherapy vs Placebo in the Treatment of Adult Patients With Alcohol Use Disorder
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Psychiatry"
DOI: 10.1001/jamapsychiatry.2022.2096
Abstract: Key Points Question Does psilocybin-assisted treatment improve drinking outcomes in patients with alcohol use disorder relative to outcomes observed with active placebo medication? Findings In this double-blind randomized clinical trial with 93 participants, the percentage… read more here.
Keywords: psilocybin; percentage heavy; placebo; drinking days ... See more keywords
P300‐mediated modulations in self–other processing under psychedelic psilocybin are related to connectedness and changed meaning: A window into the self–other overlap
Sign Up to like & getrecommendations! Published in 2020 at "Human Brain Mapping"
DOI: 10.1002/hbm.25174
Abstract: The concept of self and self‐referential processing has a growing explanatory value in psychiatry and neuroscience, referring to the cognitive organization and perceptual differentiation of self‐stimuli in health and disease. Conditions in which selfhood loses… read more here.
Keywords: changed meaning; time; psilocybin; self ... See more keywords
Diversity, biology, and history of psilocybin-containing fungi: Suggestions for research and technological development.
Sign Up to like & getrecommendations! Published in 2022 at "Fungal biology"
DOI: 10.1016/j.funbio.2022.01.003
Abstract: Therapeutic use of psilocybin has become a focus of recent international research, with preliminary data showing promise to address a range of treatment-resistant mental health conditions. However, use of psilocybin as a healing entheogen has… read more here.
Keywords: psilocybin containing; history; containing fungi; psilocybin ... See more keywords
DARK Classics in Chemical Neuroscience: Psilocybin.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.8b00186
Abstract: Psilocybin is found in a family of mushrooms commonly known as "magic mushrooms" that have been used throughout history to induce hallucinations. In the late 1950s Albert Hofmann, of Sandoz Laboratories, identified and synthesized the… read more here.
Keywords: dark classics; chemical neuroscience; classics chemical; psilocybin ... See more keywords
Psilocybin: Characterization of the Metastable Zone Width (MSZW), Control of Anhydrous Polymorphs, and Particle Size Distribution (PSD)
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.1c06708
Abstract: Psilocybin, a serotonergic agonist, was granted a “breakthrough therapy” status by the Food and Drug Administration for clinical trials involving major depressive disorder and treatment-resistant depression. The direct phosphorylation of psilocin to psilocybin that uses… read more here.
Keywords: psilocybin; particle; particle size; size distribution ... See more keywords
An Improved, Practical, and Scalable Five-Step Synthesis of Psilocybin
Sign Up to like & getrecommendations! Published in 2020 at "Synthesis"
DOI: 10.1055/s-0039-1691565
Abstract: Described herein is an improved synthesis of 3-[2-(dimethylamino)ethyl]-1H-indol-4-yl dihydrogen phosphate (psilocybin). The protocol outlines: synthesis of multigram quantities of psilocybin, identification of critical in-process parameters, and isolation of psilocybin without the use of chromatography, TLC,… read more here.
Keywords: five step; scalable five; psilocybin; practical scalable ... See more keywords
Metabolism of psilocybin and psilocin: clinical and forensic toxicological relevance
Sign Up to like & getrecommendations! Published in 2017 at "Drug Metabolism Reviews"
DOI: 10.1080/03602532.2016.1278228
Abstract: Abstract Psilocybin and psilocin are controlled substances in many countries. These are the two main hallucinogenic compounds of the “magic mushrooms” and both act as agonists or partial agonists at 5-hydroxytryptamine (5-HT)2A subtype receptors. During… read more here.
Keywords: psilocybin; relevance; psilocybin psilocin; metabolism psilocybin ... See more keywords
Psilocybin facilitates fear extinction in mice by promoting hippocampal neuroplasticity.
Sign Up to like & getrecommendations! Published in 2023 at "Chinese medical journal"
DOI: 10.1097/cm9.0000000000002647
Abstract: BACKGROUND Posttraumatic stress disorder (PTSD) and depression are highly comorbid. Psilocybin exerts substantial therapeutic effects on depression by promoting neuroplasticity. Fear extinction is a key process in the mechanism of first-line exposure-based therapies for PTSD.… read more here.
Keywords: psilocybin; hippocampal neuroplasticity; fear extinction; extinction ... See more keywords
Therapeutic mechanisms of psilocybin: Changes in amygdala and prefrontal functional connectivity during emotional processing after psilocybin for treatment-resistant depression
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Psychopharmacology"
DOI: 10.1177/0269881119895520
Abstract: Background: Psilocybin has shown promise as a treatment for depression but its therapeutic mechanisms are not properly understood. In contrast to the presumed actions of antidepressants, we recently found increased amygdala responsiveness to fearful faces… read more here.
Keywords: depression; treatment; connectivity; therapeutic mechanisms ... See more keywords
Lifetime use of MDMA/ecstasy and psilocybin is associated with reduced odds of major depressive episodes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Psychopharmacology"
DOI: 10.1177/02698811211066714
Abstract: Background: Depression is a major mental health issue worldwide, with high rates of chronicity and non-recovery associated with the condition. Existing treatments such as antidepressant medication and psychological treatments have modest effectiveness, suggesting the need… read more here.
Keywords: psilocybin; ecstasy psilocybin; past year; use ... See more keywords
Race and ethnicity moderate the associations between lifetime psychedelic use (MDMA/ecstasy and psilocybin) and major depressive episodes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Psychopharmacology"
DOI: 10.1177/02698811221127304
Abstract: Background: Psychedelics are receiving renewed attention within Western medicine as they represent potential treatments for many difficult-to-treat mental health disorders. However, psychedelic science is limited in its focus and inclusion of racial and ethnic minorities.… read more here.
Keywords: psilocybin; race ethnicity; use; mdma ecstasy ... See more keywords