Phenol-soluble modulins PSMα3 and PSMβ2 form nanotubes that are cross-α amyloids
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2121586119
Abstract: Significance The formation of cross-α amyloids has been shown by crystallographic analysis of the highly cytolytic peptide PSMα3, a secreted virulence factor associated with the human pathogen Staphylococcus aureus. However, the relationship of the crystallographic… read more here.
Keywords: psm peptides; cross amyloids; psm psm; phenol soluble ... See more keywords
Probing the drivers of Staphylococcus aureus biofilm protein amyloidogenesis and disrupting biofilms with engineered protein disaggregases
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DOI: 10.1128/mbio.00587-23
Abstract: ABSTRACT Phenol-soluble modulins (PSMs) are the primary proteinaceous component of Staphylococcus aureus biofilms. Residence in the protective environment of biofilms allows bacteria to rapidly evolve and acquire antimicrobial resistance, which can lead to persistent infections… read more here.
Keywords: psm peptides; system; aureus biofilms; staphylococcus aureus ... See more keywords