In Vivo Demonstration of PSMA Expression in Adenocarcinoma Urinary Bladder Using 68Ga-PSMA 11 PET/CT.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Nuclear Medicine"
DOI: 10.1097/rlu.0000000000001683
Abstract: In vitro and in vivo studies have demonstrated prostate-specific membrane antigen (PSMA) expression in various malignant and benign tumors. Based on the recent immunohistochemical study showing PSMA expression in adenocarcinoma of urinary bladder, we hypothesized… read more here.
Keywords: adenocarcinoma urinary; expression; urinary bladder; psma expression ... See more keywords
Investigating PSMA-Targeted Radioligand Therapy Efficacy as a Function of Cellular PSMA Levels and Intratumoral PSMA Heterogeneity
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-19-1485
Abstract: Purpose: Prostate-specific membrane antigen (PSMA) targeting radioligands deliver radiation to PSMA-expressing cells. However, the relationship between PSMA levels and intralesion heterogeneity of PSMA expression, and cytotoxic radiation by radioligand therapy (RLT) is unknown. Here we… read more here.
Keywords: radioligand; psma levels; efficacy; psma ... See more keywords
Prostate-Specific Membrane Antigen Expression and Response to DNA Damaging Agents in Prostate Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-21-4531
Abstract: Abstract Purpose: Prostate-specific membrane antigen (PSMA) targeting therapies such as Lutetium-177 (177Lu)–PSMA-617 are affecting outcomes from metastatic castration-resistant prostate cancer (mCRPC). However, a significant subset of patients have prostate cancer cells lacking PSMA expression, raising… read more here.
Keywords: prostate cancer; dna; psma expression; expression ... See more keywords
Reversible epigenetic alterations mediate PSMA expression heterogeneity in advanced metastatic prostate cancer
Sign Up to like & getrecommendations! Published in 2023 at "JCI Insight"
DOI: 10.1172/jci.insight.162907
Abstract: Prostate-specific membrane antigen (PSMA) is an important cell surface target in prostate cancer. There are limited data on the heterogeneity of PSMA tissue expression in metastatic castration-resistant prostate cancer (mCRPC). Furthermore, the mechanisms regulating PSMA… read more here.
Keywords: prostate cancer; psma expression; psma; expression ... See more keywords
Preclinical evaluation of PSMA expression in response to androgen receptor blockade for theranostics in prostate cancer
Sign Up to like & getrecommendations! Published in 2018 at "EJNMMI Research"
DOI: 10.1186/s13550-018-0451-z
Abstract: BackgroundProstate-specific membrane antigen (PSMA)-directed radioligand therapy (RLT) is a promising yet not curative approach in castration-resistant (CR) prostate cancer (PC). Rational combination therapies may improve treatment efficacy. Here, we explored the effect of androgen receptor… read more here.
Keywords: psma expression; expression; rlt; prostate cancer ... See more keywords
Upregulation of PSMA Expression by Enzalutamide in Patients with Advanced mCRPC
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14071696
Abstract: Simple Summary The prostate-specific membrane antigen (PSMA) which shows overexpression on the cell surface of prostate cancer cells, provides a specific target for molecular imaging and radioligand therapy. In this study, we investigated PSMA upregulation… read more here.
Keywords: patients advanced; prostate; medication; psma ... See more keywords
Impact of Androgen Receptor Activity on Prostate-Specific Membrane Antigen Expression in Prostate Cancer Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031046
Abstract: Prostate-specific membrane antigen (PSMA) is an essential molecular regulator of prostate cancer (PCa) progression coded by the FOLH1 gene. The PSMA protein has become an important factor in metastatic PCa diagnosis and radioligand therapy. However,… read more here.
Keywords: expression; psma expression; androgen; psma ... See more keywords
Prostate-Specific Membrane Antigen (PSMA) Expression in Tumor-Associated Neovasculature Is an Independent Prognostic Marker in Patients with Ovarian Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12040551
Abstract: Prostate-specific membrane antigen (PSMA) is present in the tumor-associated neovasculature of many cancer types. Current data in ovarian cancer are limited and controversial; thus, the aim of this study was to investigate PSMA expression in… read more here.
Keywords: ovarian cancer; tumor associated; psma; cancer ... See more keywords
Prostate-specific membrane antigen expression in hepatocellular carcinoma, cholangiocarcinoma, and liver cirrhosis
Sign Up to like & getrecommendations! Published in 2020 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v26.i48.7664
Abstract: BACKGROUND Primary liver cancer includes three subtypes: Hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (CCA), and combined hepatocellular carcinoma. Patients with primary liver cancer experienced poor prognosis and high mortality, so early detection of liver cancer and… read more here.
Keywords: liver cirrhosis; liver; expression; psma expression ... See more keywords