Targeted delivery of cytotoxic proteins to prostate cancer via conjugation to small molecule urea-based PSMA inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-94534-5
Abstract: Prostate cancer cells are characterized by a remarkably low proliferative rate and the production of high levels of prostate-specific proteases. Protein-based toxins are attractive candidates for prostate cancer therapy because they kill cells via proliferation-independent… read more here.
Keywords: prostate cancer; urea based; cancer cells; cancer ... See more keywords
Evolution of Peptide-Based Prostate-Specific Membrane Antigen (PSMA) Inhibitors: An Approach to Novel Prostate Cancer Therapeutics.
Sign Up to like & getrecommendations! Published in 2020 at "Current medicinal chemistry"
DOI: 10.2174/0929867327666201006153847
Abstract: BACKGROUND Prostate cancer is one of the most common cancers worldwide, with approximately 1.1 million cases diagnosed annually. The rapid development of molecular imaging has facilitated greater structural understanding which can help formulate novel combination… read more here.
Keywords: psma inhibitors; prostate specific; prostate; prostate cancer ... See more keywords