LncRNA HCP5 promotes LAML progression via PSMB8-mediated PI3K/AKT pathway activation
Sign Up to like & getrecommendations! Published in 2019 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-019-01788-y
Abstract: Acute myeloid leukemia is an aggressive myeloid malignancy, characterized by rapid cellular proliferation and generally high mortality. Due to the lack of a complete understanding of AML, its clinical outcomes are still not satisfactory. In… read more here.
Keywords: hcp5; pathway activation; pi3k akt; psmb8 ... See more keywords
Blockade of the CXCR3/CXCL10 axis ameliorates inflammation caused by immunoproteasome dysfunction
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.152681
Abstract: Immunoproteasomes regulate the degradation of ubiquitin-coupled proteins and generate peptides that are preferentially presented by MHC class I. Mutations in immunoproteasome subunits lead to immunoproteasome dysfunction, which causes proteasome-associated autoinflammatory syndromes (PRAAS) characterized by nodular… read more here.
Keywords: psmb8 mice; psmb8; cxcr3; immunoproteasome dysfunction ... See more keywords
Analysis on methylation and expression of PSMB8 and its correlation with immunity and immunotherapy in lung adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Epigenomics"
DOI: 10.2217/epi-2022-0282
Abstract: Aim: To find biomarkers for immunity and immunotherapy in lung adenocarcinoma (LUAD) through multiomics analysis. Materials & methods: The multiomics data of patients with LUAD were downloaded from the TCGA and GEO databases. CIBERSORT, quanTIseq,… read more here.
Keywords: lung adenocarcinoma; psmb8; immunity immunotherapy; immunotherapy lung ... See more keywords