Simultaneous characterisation of multiple Psoraleae Fructus bioactive compounds in rat plasma by ultra-high-performance liquid chromatography coupled with triple quadrupole mass Spectrometry for application in sex-related differences in pharmacokinetics.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of separation science"
DOI: 10.1002/jssc.202000286
Abstract: A method for the simultaneous quantification of thirteen bioactive compounds (psoralen, isopsoralen, isobavachin, bakuchalcone, neobabaisoflavone, bavachin, corylin, psoralidin, isobavachalcone, bavachinin, corylifol A, bavachalcone and bakuchiol) by ultra-high-performance liquid chromatography coupled with triple quadrupole mass Spectrometry… read more here.
Keywords: liquid; psoraleae fructus; ultra high; bioactive compounds ... See more keywords
Psoralidin, a major component of Psoraleae Fructus, induces inflammasome activation and idiosyncratic liver injury.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.107352
Abstract: Idiosyncratic drug-induced liver injury (IDILI) is a rare but potentially fatal disease that is unpredictable and independent of the dose of the drug. Increasing evidence suggests that the majority of IDILI cases are immune-mediated, and… read more here.
Keywords: inflammasome activation; psoraleae fructus; psoralidin; activation ... See more keywords
Psoralen and Isopsoralen, Two Estrogen-Like Natural Products from Psoraleae Fructus, Induced Cholestasis via Activation of ERK1/2.
Sign Up to like & getrecommendations! Published in 2024 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.4c00054
Abstract: With the increasing use of oral contraceptives and estrogen replacement therapy, the incidence of estrogen-induced cholestasis (EC) has tended to rise. Psoralen (P) and isopsoralen (IP) are the major bioactive components in Psoraleae Fructus, and… read more here.
Keywords: psoralen isopsoralen; estrogen like; psoraleae fructus; induced cholestasis ... See more keywords